Skip to main content

Advertisement

Log in

Unusual eye findings in a patient with atypical hemolytic uremic syndrome: Answers

  • Clinical Quiz
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Tsai HM (2006) The molecular biology of thrombotic microangiopathy. Kidney Int 70:16–23. https://doi.org/10.1038/sj.ki.5001535

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Sturm V, Menke MN, Landau K, Laube GF, Neuhaus TJ (2010) Ocular involvement in paediatric haemolytic uraemic syndrome. Acta Ophthalmol 88:804–807. https://doi.org/10.1111/j.1755-3768.2009.01552.x

    Article  PubMed  Google Scholar 

  3. Formeck C, Swiatecka-Urban A (2019) Extra-renal manifestations of atypical hemolytic uremic syndrome. Pediatr Nephrol 34:1337–1348. https://doi.org/10.1007/s00467-018-4039-7

    Article  PubMed  Google Scholar 

  4. Greenwood GT (2015) Case report of atypical hemolytic uremic syndrome with retinal arterial and venous occlusion treated with eculizumab. Int Med Case Rep J 8:235–239. https://doi.org/10.2147/IMCRJ.S90640

    Article  PubMed  PubMed Central  Google Scholar 

  5. David R, Hochberg-Klein S, Amer R (2013) Resolution of ocular involvement with systemic eculizumab therapy in atypical hemolytic-uremic syndrome. Eye 27:997–998. https://doi.org/10.1038/eye.2013.111

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Lin IH, Chen YJ, Chang PY, Hsiao PW, Weng TH, Chang YH (2019) Bilateral proliferative retinopathy and ischemic optic neuropathy in a patient with atypical hemolytic-uremic syndrome: a case report. Medicine 98:e17232. https://doi.org/10.1097/MD.0000000000017232

    Article  PubMed  PubMed Central  Google Scholar 

  7. Polito MS, Machetta F, Fea AM, Eandi CM (2021) Hypertensive choroidopathy in atypical hemolytic-uremic syndrome. Eur J Ophthalmol 31:NP63–NP66. https://doi.org/10.1177/1120672119896286

    Article  PubMed  Google Scholar 

  8. Ramos de Carvalho JE, Schlingemann RO, Oranje M, Bemelman FJ, van Schooneveld MJ (2018) Reversal of threatening blindness after initiation of eculizumab in Purtscher-like retinopathy secondary to atypical hemolytic uremic syndrome. Int Ophthalmol 38:399–407. https://doi.org/10.1007/s10792-017-0470-1

    Article  CAS  PubMed  Google Scholar 

  9. Rooney JC, Anderson RM, Hopkins IJ (1971) Clinical and pathological aspects of central nervous system involvement in the haemolytic uraemic syndrome. Aust Paediatr J 7:28–33. https://doi.org/10.1111/j.1440-1754.1971.tb02465.x

    Article  CAS  PubMed  Google Scholar 

  10. Sheth KJ, Swick HM, Haworth N (1986) Neurological involvement in hemolytic-uremic syndrome. Ann Neurol 19:90–93. https://doi.org/10.1002/ana.410190120

    Article  CAS  PubMed  Google Scholar 

  11. Siegler RL, Brewer ED, Swartz M (1988) Ocular involvement in hemolytic-uremic syndrome. J Pediatr 112:594–597. https://doi.org/10.1016/s0022-3476(88)80178-1

    Article  CAS  PubMed  Google Scholar 

  12. Lauer AK, Klein ML, Kovarik WD, Palmer EA (1998) Hemolytic uremic syndrome associated with Purtscher-like retinopathy. Arch Ophthalmol 116:1119–1120

    CAS  PubMed  Google Scholar 

  13. Krott R, Querfeld U, Bartz-Schmidt KU, Hammers H, Hammers W, Heimann K (1999) Progressive subretinal fibrosis in a child following hemolytic uremic syndrome. Retina 19:77–79. https://doi.org/10.1097/00006982-199901000-00014

    Article  CAS  PubMed  Google Scholar 

  14. Larakeb A, Leroy S, Frémeaux-Bacchi V, Montchilova M, Pelosse B, Dunand O, Deschênes G, Bensman A, Ulinski T (2007) Ocular involvement in hemolytic uremic syndrome due to factor H deficiency–are there therapeutic consequences? Pediatr Nephrol 22:1967–1970. https://doi.org/10.1007/s00467-007-0540-0

    Article  PubMed  Google Scholar 

  15. Gulleroglu K, Fidan K, Hançer VS, Bayrakci U, Baskin E, Soylemezoglu O (2013) Neurologic involvement in atypical hemolytic uremic syndrome and successful treatment with eculizumab. Pediatr Nephrol 28:827–830. https://doi.org/10.1007/s00467-013-2416-9

    Article  PubMed  Google Scholar 

  16. Zheng X, Gorovoy IR, Mao J, Jin J, Chen X, Cui QN (2014) Recurrent ocular involvement in pediatric atypical hemolytic uremic syndrome. J Pediatr Ophthalmol Strabismus 51:e62–e65. https://doi.org/10.3928/01913913-20140923-03

    Article  PubMed  Google Scholar 

  17. Morel-Maroger L, Kanfer A, Solez K, Sraer JD, Richet G (1979) Prognostic importance of vascular lesions in acute renal failure with microangiopathic hemolytic anemia (hemolytic-uremic syndrome): clinicopathologic study in 20 adults. Kidney Int 15:548–558. https://doi.org/10.1038/ki.1979.70

    Article  CAS  PubMed  Google Scholar 

  18. Catón B, Díaz de Otazu R, Aldamiz-Echebarria M, Viguri A (1993) Haemolytic-uraemic syndrome with thrombotic microangiopathy of the retina following cytomegalovirus infection: postmortem findings. Postgrad Med J 69:653–655. https://doi.org/10.1136/pgmj.69.814.653

    Article  PubMed  PubMed Central  Google Scholar 

  19. Eberhard OK, Labjuhn SO, Olbricht CJ (1995) Ocular involvement in haemolytic uraemic syndrome–case report and review of the literature. Nephrol Dial Transplant 10:266–269

    CAS  PubMed  Google Scholar 

  20. González DP, Iglicki M, Svetitsky S, Bar-On Y, Habot-Wilner Z, Zur D (2021) Occlusive retinal vasculopathy with macular branch retinal artery occlusion as a leading sign of atypical hemolytic uremic syndrome - a case report. BMC Ophthalmol 21:65. https://doi.org/10.1186/s12886-021-01820-x

    Article  PubMed  PubMed Central  Google Scholar 

  21. Ahn SJ, Woo SJ, Jin Y, Chang YS, Kim TW, Ahn J, Heo JW, Yu HG, Chung H, Park KH, Hong ST (2014) Clinical features and course of ocular toxocariasis in adults. PLoS Negl Trop Dis 8:e2938. https://doi.org/10.1371/journal.pntd.0002938

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Martínez-Pulgarín DF, Muñoz-Urbano M, Gomez-Suta LD, Delgado OM, Rodriguez-Morales AJ (2015) Ocular toxocariasis: new diagnostic and therapeutic perspectives. Recent Pat Antiinfect Drug Discov 10:35–41. https://doi.org/10.2174/1574891x10666150410125057

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Begüm Avcı.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This refers to the article that can be found at https://doi.org/10.1007/s00467-021-05353-9

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Avcı, B., Özdek, Ş., Akkoyun, İ. et al. Unusual eye findings in a patient with atypical hemolytic uremic syndrome: Answers. Pediatr Nephrol 37, 1531–1537 (2022). https://doi.org/10.1007/s00467-021-05376-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-021-05376-2

Keywords

Navigation