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Rickets, elevated fibroblast growth factor-23 and mild anemia: Answers

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References

  1. Tiosano D, Hochberg Z (2009) Hypophosphatemia: the common denominator of all rickets. J Bone Miner Metab 27:392–401

    Article  Google Scholar 

  2. Penido MG, Alon US (2014) Hypophosphatemic rickets due to perturbations in renal tubular function. Pediatr Nephrol 29:361–373

    Article  Google Scholar 

  3. Alon US (2011) Fibroblast growth factor (FGF)23: a new hormone. Eur J Pediatr 170:545–554

    Article  CAS  Google Scholar 

  4. Eyskens B, Proesmans W, Damme V, Lauter L, Bouillon R, Hoogmarten M (1995) Tumor-induced rickets: a case report and review of the literature. Eur J Pediatr 154:462–464

    Article  CAS  Google Scholar 

  5. Holm IA, Econs MJ, Carpenter TO (2012) Familial hypophosphatemia and related disorders. In: Glorieux FH, Pettifor JM, Juppner H (eds) Pediatric bone, 2nd edn. Elsevier, Amsterdam, pp 699–726

    Chapter  Google Scholar 

  6. Bitzan M, Goodyer PR (2019) Hypophosphatemic rickets. Pediatr Clin North Am 66:179–207. https://doi.org/10.1016/j.pcl.2018.09.004

    Article  PubMed  Google Scholar 

  7. Imel EA, Peacock M, Gray AK, Padgett LR, Hui SL, Econs MJ (2011) Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans. J Clin Endocrinol Metab 96:3541–3549. https://doi.org/10.1210/jc.2011-1239

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Liu C, Li X, Zhao Z, Chi Y, Cui L, Zhang Q, Ping F, Chai X, Jiang Y, Wang O, Li M, Xing X, Xia W (2020) Iron deficiency plays essential roles in the trigger, treatment, and prognosis of autosomal dominant hypophosphatemic rickets. Osteoporos Int. https://doi.org/10.1007/s00198-020-05649-w

  9. Winters RW, Graham JB, Williams TF, McFalls VW, Burnett CH (1991) A genetic study of familial hypophosphatemia and vitamin D resistant rickets with a review of the literature. 1958. Medicine (Baltimore) 70:215–217

    Article  CAS  Google Scholar 

  10. Eicher EM, Southard JL, Scriver CR, Glorieux FH (1976) Hypophosphatemia: mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets. Proc Natl Acad Sci U S A 73:4667–4671. https://doi.org/10.1073/pnas.73.12.4667

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Högler W, Kapelari K (2020) Oral iron for prevention and treatment of rickets and osteomalacia in autosomal dominant hypophosphatemia. J Bone Miner Res 35:226–230. https://doi.org/10.1002/jbmr.3941

    Article  CAS  PubMed  Google Scholar 

  12. Liu S, Tang W, Zhou J, Stubbs JR, Luo Q, Pi M, Quarles LD (2006) Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J Am Soc Nephrol 17:1305–1315. https://doi.org/10.1681/ASN.2005111185

    Article  CAS  PubMed  Google Scholar 

  13. Bielesz B, Reiter T, Hammerle FP, Winnicki W, Bojic M, Gleiss A, Kieweg H, Ratzinger F, Sunder-Plassmann G, Marculescu R (2020) The role of iron and erythropoietin in the association of fibroblast growth factor 23 with anemia in chronic kidney disease in humans. J Clin Med 9:2640. https://doi.org/10.3390/jcm9082640

    Article  CAS  PubMed Central  Google Scholar 

  14. Komaba H, Fukagawa M (2012) The role of FGF23 in CKD—with or without Klotho. Nat Rev Nephrol 8:484–490. https://doi.org/10.1038/nrneph.2012.116

    Article  CAS  PubMed  Google Scholar 

  15. Francis C, Courbon G, Gerber C, Neuburg S, Wang X, Dussold C, Capella M, Qi L, Isakova T, Mehta R, Martin A, Wolf M, David V (2019) Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease. Kidney Int 96:1346–1358. https://doi.org/10.1016/j.kint.2019.07.026

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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The authors thank the family for giving us the permission to publish the case.

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Correspondence to Judith Sebestyen VanSickle.

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VanSickle, J.S., Srivastava, T., Monachino, P. et al. Rickets, elevated fibroblast growth factor-23 and mild anemia: Answers. Pediatr Nephrol 36, 2301–2304 (2021). https://doi.org/10.1007/s00467-021-05012-z

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