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Substance use among adolescents and young adults with chronic kidney disease or kidney failure

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Abstract

Substance use, a significant public health issue, is well described in the adult chronic kidney disease (CKD) population. Knowledge about substance use in the adolescent and young adult (AYA) CKD population such as prevalence, impact on kidney function, medication adherence, and psychosocial well-being remain largely unknown. Awareness of and inquiring about substance use is paramount to providing evidence-based care and preparation to transition to adult-focused health services. The authors in this review identify commonly used substances (alcohol, tobacco, marijuana, etc.) and how they impact kidney function and care of the AYA with CKD or kidney failure. Recommendations for screening and intervention strategies are provided.

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References

  1. Bundy JD, Bazzano LA, Xie D, Cohan J, Dolata J, Fink JC, Hsu CY, Jamerson K, Lash J, Makos G, Steigerwalt S, Wang X, Mills KT, Chen J, He J, CRIC Study Investigators (2018) Self-reported tobacco, alcohol, and illicit drug use and progression of chronic kidney disease. Clin J Am Soc Nephrol 13:993–1001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Chambers RA, Taylor JR, Potenza MN (2003) Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability. Am J Psychiatry 160:1041–1052

    Article  PubMed  PubMed Central  Google Scholar 

  3. Hingson RW, Zha W (2009) Age of drinking onset, alcohol use disorders, frequent heavy drinking, and unintentionally injuring oneself and others after drinking. Pediatrics 123:1477–1484

    Article  PubMed  Google Scholar 

  4. Levy SJ, Williams JF, COMMITTEE ON SUBSTANCE USE AND PREVENTION (2016) Substance Use Screening, Brief Intervention, and Referral to Treatment. Pediatrics 138:e20161211

  5. Centers for Disease Control and Prevention (US); National Center for Chronic Disease Prevention and Health Promotion (US); Office on Smoking and Health (US) (2010) How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease: a report of the surgeon general. Atlanta (GA): Centers for Disease Control and Prevention (US). PMID: 21452462

  6. Palamar JJ, Zhou S, Sherman S, Weitzman M (2014) Hookah use among U.S. high school seniors. Pediatrics 134:227–234

    Article  PubMed  PubMed Central  Google Scholar 

  7. Hawkins SS, Bach N, Baum CF (2018) Impact of tobacco control policies on adolescent smokeless tobacco and cigar use: a difference-in-differences approach. BMC Public Health 18:154

    Article  PubMed  PubMed Central  Google Scholar 

  8. Soneji SS, Knutzen KE, Villanti AC (2019) Use of flavored E-cigarettes among adolescents, young Adults, and older adults: findings from the population assessment for tobacco and health study. Public Health Rep 134:282–292

    Article  PubMed  PubMed Central  Google Scholar 

  9. Yamamoto R, Nagasawa Y, Shoji T, Iwatani H, Hamano T, Kawada N, Inoue K, Uehata T, Kaneko T, Okada N, Moriyama T, Horio M, Yamauchi A, Tsubakihara Y, Imai E, Rakugi H, Isaka Y (2010) Cigarette smoking and progression of IgA nephropathy. Am J Kidney Dis 56:313–324

    Article  CAS  PubMed  Google Scholar 

  10. Orth SR, Schroeder T, Ritz E, Ferrari P (2005) Effects of smoking on renal function in patients with type 1 and type 2 diabetes mellitus. Nephrol Dial Transplant 20:2414–2419

    Article  PubMed  Google Scholar 

  11. Zitt N, Kollerits B, Neyer U, Mark W, Heininger D, Mayer G, Kronenberg F, Lhotta K (2007) Cigarette smoking and chronic allograft nephropathy. Nephrol Dial Transplant 22:3034–3039

    Article  CAS  PubMed  Google Scholar 

  12. Omoloja A, Jerry-Fluker J, Ng DK, Abraham AG, Furth S, Warady BA, Mitsnefes M (2013) Secondhand smoke exposure is associated with proteinuria in children with chronic kidney disease. Pediatr Nephrol 28:1243–1251

    Article  PubMed  PubMed Central  Google Scholar 

  13. García-Esquinas E, Loeffler LF, Weaver VM, Fadrowski JJ, Navas-Acien A (2013) Kidney function and tobacco smoke exposure in US adolescents. Pediatrics 131:1415

    Article  Google Scholar 

  14. Omoloja A, Chand D, Greenbaum L, Wilson A, Bastian V, Ferris M, Bernert J, Stolfi A, Patel H (2011) Cigarette smoking and second-hand smoking exposure in adolescents with chronic kidney disease: a study from the Midwest Pediatric Nephrology Consortium. Nephrol Dial Transplant 26:908–913

    Article  CAS  PubMed  Google Scholar 

  15. Xiao N, Stolfi A, Malatesta-Muncher R, Bholah R, Kogon A, Eddington A, Chand D, Greenbaum LA, Hanevold C, Tran CL, Chishti A, Davis K, Matloff R, Woroniecki R, Klosterman C, Luckritz K, Omoloja A (2019) Risk behaviors in teens with chronic kidney disease: a study from the Midwest Pediatric Nephrology Consortium. Int J Nephrol 2019:7828406

    Article  PubMed  PubMed Central  Google Scholar 

  16. Omoloja A, Tyc VL (2015) Tobacco and the pediatric chronic kidney disease population. Pediatr Nephrol 30:235–243

    Article  PubMed  Google Scholar 

  17. Kann L, McManus T, Harris WA, Shanklin SL, Flint KH, Queen B, Lowry R, Chyen D, Whittle L, Thornton J, Lim C, Bradford D, Yamakawa Y, Leon M, Brener N (2018) Ethier KA (2018) Youth risk behavior surveillance - United States, 2017. MMWR Surveill Summ 67:1–114

    Article  PubMed  PubMed Central  Google Scholar 

  18. Evans-Polce RJ, Patrick ME, Lanza ST, Miech RA, O'Malley PM, Johnston LD (2018) Reasons for vaping among U.S. 12th Graders. J Adolesc Health 62:457–462

    Article  PubMed  Google Scholar 

  19. Kalkhoran S, Glantz SA (2016) E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis. Lancet Respir Med 4:116–128

    Article  PubMed  PubMed Central  Google Scholar 

  20. Miech R, Johnston L, O'Malley PM, Bachman JG, Patrick ME (2019) Trends in adolescent vaping, 2017-2019. N Engl J Med 381:1490–1491

    Article  PubMed  PubMed Central  Google Scholar 

  21. Kosmider L, Sobczak A, Prokopowicz A, Kurek J, Zaciera M, Knysak J, Smith D, Goniewicz ML (2016) Cherry-flavoured electronic cigarettes expose users to the inhalation irritant, benzaldehyde. Thorax 71:376–377

    Article  PubMed  Google Scholar 

  22. Leventhal AM, Goldenson NI, Cho J, Kirkpatrick MG, McConnell RS, Stone MD, Pang RD, Audrain-McGovern J, Barrington-Trimis JL (2019) Flavored E-cigarette use and progression of vaping in adolescents. Pediatrics:144

  23. Antoniewicz L, Brynedal A, Hedman L, Lundbäck M, Bosson JA (2019) Acute effects of electronic cigarette inhalation on the vasculature and the conducting airways. Cardiovasc Toxicol 19:441–450

    Article  PubMed  PubMed Central  Google Scholar 

  24. Franzen KF, Willig J, Cayo Talavera S, Meusel M, Sayk F, Reppel M, Dalhoff K, Mortensen K, Droemann D (2018) E-cigarettes and cigarettes worsen peripheral and central hemodynamics as well as arterial stiffness: a randomized, double-blinded pilot study. Vasc Med 23:419–425

    Article  PubMed  Google Scholar 

  25. Wiener RC, Waters C, Bhandari R, Trickett Shockey AK, Alshaarawy O (2020) The association of sleep duration and the use of electronic cigarettes, NHANES, 2015-2016. Sleep Disord 2020:8010923

    Article  PubMed  PubMed Central  Google Scholar 

  26. Ruszkiewicz JA, Zhang Z, Gonçalves FM, Tizabi Y, Zelikoff JT, Aschner M (2020) Neurotoxicity of e-cigarettes. Food Chem Toxicol 138:111245

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Corriden R, Moshensky A, Bojanowski CM, Meier A, Chien J, Nelson RK, Crotty Alexander LE (2020) E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation. Am J Phys Cell Phys 318:C205–C214

    CAS  Google Scholar 

  28. Madison MC, Landers CT, Gu B-H, Chang C-Y, Tung H-Y, You R, Hong MJ, Baghaei N, Song L-Z, Porter P, Putluri N, Salas R, Gilbert BE, Levental I, Campen MJ, Corry DB, Kheradmand F (2019) Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine. J Clin Invest 129:4290–4304

    Article  PubMed  PubMed Central  Google Scholar 

  29. Sussan TE, Gajghate S, Thimmulappa RK, Ma J, Kim J-H, Sudini K, Consolini N, Cormier SA, Lomnicki S, Hasan F, Pekosz A, Biswal S (2015) Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLoS One 10:e0116861

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  30. Crotty Alexander LE, Drummond CA, Hepokoski M, Mathew D, Moshensky A, Willeford A, Das S, Singh P, Yong Z, Lee JH, Vega K, Du A, Shin J, Javier C, Tian J, Brown JH, Breen EC (2018) Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Phys Regul Integr Comp Phys 314:R834–R847

    CAS  Google Scholar 

  31. Tang M-S, Wu X-R, Lee H-W, Xia Y, Deng F-M, Moreira AL, Chen L-C, Huang WC, Lepor H (2019) Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice. Proc Natl Acad Sci U S A 116:21727–21731

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Adkins SH, Anderson KN, Goodman AB, Twentyman E, Danielson ML, Kimball A, Click ES, Ko JY, Evans ME, Weissman DN, Melstrom P, Kiernan E, Krishnasamy V, Rose DA, Jones CM, King BA, Ellington SR, Pollack LA, Wiltz JL (2020) Demographics, substance use behaviors, and clinical characteristics of adolescents with e-cigarette, or vaping, product use-associated lung injury (EVALI) in the United States in 2019. JAMA Pediatr 174:e200756

    Article  PubMed  PubMed Central  Google Scholar 

  33. Trivers KF, Phillips E, Gentzke AS, Tynan MA, Neff LJ (2018) Prevalence of cannabis use in electronic cigarettes among US youth. JAMA Pediatr 172:1097–1099

    Article  PubMed  PubMed Central  Google Scholar 

  34. Primack BA, Sidani J, Agarwal AA, Shadel WG, Donny EC, Eissenberg TE (2008) Prevalence of and associations with waterpipe tobacco smoking among U.S. university students. Ann Behav Med 36:81–86

    Article  PubMed  Google Scholar 

  35. Ryan SA, Kokotailo P, COMMITTEE ON SUBSTANCE USE AND PREVENTION (2019) Alcohol use by youth. Pediatrics 144:e20191357

    Article  PubMed  Google Scholar 

  36. Joo YS, Koh H, Nam KH, Lee S, Kim J, Lee C, Yun H-R, Park JT, Kang EW, Chang TI, Yoo T-H, Oh K-H, Chae DW, Lee K-B, Kim SW, Lee J, Kang S-W, Choi KH, Ahn C, Han SH (2020) Alcohol consumption and progression of chronic kidney disease: results from the Korean cohort study for outcome in patients with chronic kidney disease. Mayo Clin Proc 95:293–305

    Article  PubMed  Google Scholar 

  37. Cheungpasitporn W, Thongprayoon C, Kittanamongkolchai W, Brabec BA, O'Corragain OA, Edmonds PJ, Erickson SB (2015) High alcohol consumption and the risk of renal damage: a systematic review and meta-analysis. QJM 108:539–548

    Article  CAS  PubMed  Google Scholar 

  38. Carbia C, Cadaveira F, Caamaño-Isorna F, Rodríguez-Holguín S, Corral M (2017) Binge drinking during adolescence and young adulthood is associated with deficits in verbal episodic memory. PLoS One 12:e0171393

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  39. Ruebner RL, Laney N, Kim JY, Hartung EA, Hooper SR, Radcliffe J, Furth SL (2016) Neurocognitive dysfunction in children, Adolescents, and Young Adults With CKD. Am J Kidney Dis 67:567–575

    Article  PubMed  Google Scholar 

  40. Weitzman ER, Magane KM, Wisk LE, Allario J, Harstad E, Levy S (2018) Alcohol use and alcohol-interactive medications among medically vulnerable youth. Pediatrics 142:e20174026

    Article  PubMed  Google Scholar 

  41. Johnson BA, Seneviratne C (2014) Alcohol-medical drug interactions. Handb Clin Neurol 125:543–559

    Article  PubMed  Google Scholar 

  42. Thomas AA, Von Derau K, Bradford MC, Moser E, Garrard A, Mazor S (2019) Unintentional pediatric marijuana exposures prior to and after legalization and commercial availability of recreational marijuana in Washington State. J Emerg Med 56:398–404

    Article  PubMed  Google Scholar 

  43. McPartland JM, Duncan M, Di Marzo V, Pertwee RG (2015) Are cannabidiol and Delta(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol 172:737–753

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Rein JL (2020) The nephrologist’s guide to cannabis and cannabinoids. Curr Opin Nephrol Hypertens 29:248–257

    Article  PubMed  PubMed Central  Google Scholar 

  45. Barutta F, Bruno G, Mastrocola R, Bellini S, Gruden G (2018) The role of cannabinoid signaling in acute and chronic kidney diseases. Kidney Int 94:252–258

    Article  CAS  PubMed  Google Scholar 

  46. Kaur R, Ambwani SR, Singh S (2016) Endocannabinoid system: a multi-facet therapeutic target. Curr Clin Pharmacol 11:110–117

    Article  CAS  PubMed  Google Scholar 

  47. Jenkin KA, O'Keefe L, Simcocks AC, Briffa JF, Mathai ML, McAinch AJ, Hryciw DH (2016) Renal effects of chronic pharmacological manipulation of CB2 receptors in rats with diet-induced obesity. Br J Pharmacol 173:1128–1142

    Article  CAS  PubMed  Google Scholar 

  48. Ishida JH, Auer R, Vittinghoff E, Pletcher MJ, Reis JP, Sidney S, Johansen KL, Bibbins-Domingo K, Peralta CA, Shlipak MG (2017) Marijuana use and estimated glomerular filtration rate in young adults. Clin J Am Soc Nephrol 12:1578–1587

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Lu C, Papatheodorou SI, Danziger J, Mittleman MA (2018) Marijuana use and renal function among US adults. Am J Med 131:408–414

    Article  PubMed  Google Scholar 

  50. Greenan G, Ahmad SB, Anders MG, Leeser A, Bromberg JS, Niederhaus SV (2016) Recreational marijuana use is not associated with worse outcomes after renal transplantation. Clin Transpl 30:1340–1346

    Article  CAS  Google Scholar 

  51. Rai HS, Winder GS (2017) Marijuana use and organ transplantation: a review and implications for clinical practice. Curr Psychiatry Rep 19:91

    Article  PubMed  Google Scholar 

  52. Ruckle D, Keheila M, West B, Baron P, Villicana R, Mattison B, Thomas A, Thomas J, De Vera M, Kore A, Wai P, Baldwin DD (2019) Should donors who have used marijuana be considered candidates for living kidney donation? Clin Kidney J 12:437–442

    Article  PubMed  Google Scholar 

  53. Alhamad T, Koraishy FM, Lam NN, Katari S, Naik AS, Schnitzler MA, Xiao H, Axelrod DA, Dharnidharka VR, Randall H, Ouseph R, Segev DL, Brennan DC, Devraj R, Kasiske BL, Lentine KL (2019) Cannabis dependence or abuse in kidney transplantation: implications for posttransplant outcomes. Transplantation 103:2373–2382

    Article  PubMed  PubMed Central  Google Scholar 

  54. Stark AL, Hickson LJ, Larrabee BR, Thusius NJ, Karpyak VM, Hall-Flavin DK, Schneekloth TD (2019) Cannabis abuse and dependence in kidney transplant candidates. J Psychosom Res 121:68–73

    Article  PubMed  PubMed Central  Google Scholar 

  55. Ladegard K, Thurstone C, Rylander M (2020) Marijuana legalization and Yyouth. Pediatrics 145:S165–S174

    Article  PubMed  Google Scholar 

  56. Jiang R, Yamaori S, Okamoto Y, Yamamoto I, Watanabe K (2013) Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Drug Meta Pharmacokinet 28:332–338

    Article  CAS  Google Scholar 

  57. Cooks T, Davis TK, Hu J, Metheny R, Schwartz M, Gerona R (2016) “Smoking” guns: questions. “Smoking” guns: answers. Pediatr Nephrol 31:61–66

    Article  PubMed  Google Scholar 

  58. Palamar JJ, Acosta P (2015) Synthetic cannabinoid use in a nationally representative sample of US high school seniors. Drug Alcohol Depend 149:194–202

    Article  PubMed  PubMed Central  Google Scholar 

  59. Silva JP, Carmo H, Carvalho F (2018) The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis. Toxicol Lett 287:59–69

    Article  CAS  PubMed  Google Scholar 

  60. Isoardi KZ, Ayles SF, Harris K, Finch CJ, Page CB (2019) Methamphetamine presentations to an emergency department: management and complications. Emerg Med Australas 31:593–599

    Article  PubMed  Google Scholar 

  61. Steele TD, McCann UD, Ricaurte GA (1994) 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans. Addiction 89:539–551

    Article  CAS  PubMed  Google Scholar 

  62. Johnston LD, Miech RA, O’Malley PM, Bachman JG, Schulenberg JE, Patrick ME (2020). Monitoring the Future. National survey results on drug use 1975-2019: overview, key findings on adolescent drug use. Institute for Social Research, University of Michigan, Ann Arbor

  63. Meredith CW, Jaffe C, Ang-Lee K, Saxon AJ (2005) Implications of chronic methamphetamine use: a literature review. Harv Rev Psychiatry 13:141–154

    Article  PubMed  Google Scholar 

  64. Vorhees CV, He E, Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Amos-Kroohs R, Williams MT (2011) Comparison of (+)-methamphetamine, +/--methylenedioxymethamphetamine, (+)-amphetamine and +/--fenfluramine in rats on egocentric learning in the Cincinnati water maze. Synapse 65:368–378

    Article  CAS  PubMed  Google Scholar 

  65. Pendergraft WF 3rd, Herlitz LC, Thornley-Brown D, Rosner M, Niles JL (2014) Nephrotoxic effects of common and emerging drugs of abuse. Clin J Am Soc Nephrol 9:1996–2005

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Isoardi KZ, Mudge DW, Harris K, Dimeski G, Buckley NA (2020) Methamphetamine intoxication and acute kidney injury: a prospective observational case series. Nephrology (Carlton) 25:758–764

  67. Akkina SK, Ricardo AC, Patel A, Das A, Bazzano LA, Brecklin C, Fischer MJ, Lash JP (2012) Illicit drug use, hypertension, and chronic kidney disease in the US adult population. Transl Res 160:391–398

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Mansoor K, Kheetan M, Shahnawaz S, Shapiro AP, Patton-Tackett E, Dial L, Rankin G, Santhanam P, Tzamaloukas AH, Nadasdy T, Shapiro JI, Khitan ZJ (2017) Systematic review of nephrotoxicity of drugs of abuse, 2005-2016. BMC Nephrol 18:379

    Article  PubMed  PubMed Central  Google Scholar 

  69. Bingham C, Beaman M, Nicholls AJ, Anthony PP (1998) Necrotizing renal vasculopathy resulting in chronic renal failure after ingestion of methamphetamine and 3,4-methylenedioxymethamphetamine (‘ecstasy’). Nephrol Dial Transplant 13:2654–2655

    Article  CAS  PubMed  Google Scholar 

  70. NIDA (2020) Synthetic cathinones (“Bath Salts”) drug facts. Retrieved from https://www.drugabuse.gov/publications/drugfacts/synthetic-cathinones-bath-salts. Accessed January 13, 2021

  71. Palamar JJ, Rutherford C, Keyes KM (2019) “Flakka” use among high school seniors in the United States. Drug Alcohol Depend 196:86–90

    Article  PubMed  PubMed Central  Google Scholar 

  72. Schifano F, Napoletano F, Arillotta D, Zangani C, Gilgar L, Guirguis A, Corkery JM, Vento A (2020) The clinical challenges of synthetic cathinones. Br J Clin Pharmacol 86:410–419

    Article  PubMed  PubMed Central  Google Scholar 

  73. Miech RA, Johnston LD, O’Malley PM, Bachman JG, Schulenberg JE, Patrick ME (2020) Monitoring the future: national survey results on drug use, 1975–2019: Volume I, Secondary school students. Ann Arbor: Institute for Social Research, The University of Michigan. http://monitoringthefuture.org/pubs.html#monographs, Accessed January 13, 2021

  74. Liechti M (2015) Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling. Swiss Med Wkly 145:w14043

    PubMed  Google Scholar 

  75. Miotto K, Striebel J, Cho AK, Wang C (2013) Clinical and pharmacological aspects of bath salt use: a review of the literature and case reports. Drug Alcohol Depend 132:1–12

    Article  CAS  PubMed  Google Scholar 

  76. Regunath H, Ariyamuthu VK, Dalal P, Misra M (2012) Bath salt intoxication causing acute kidney injury requiring hemodialysis. Hemodial Int 16(Suppl 1):S47–S49

    Article  PubMed  Google Scholar 

  77. Crowe AV, Howse M, Bell GM, Henry JA (2000) Substance abuse and the kidney. QJM 93:147–152

    Article  CAS  PubMed  Google Scholar 

  78. Nzerue CM, Hewan-Lowe K, Riley LJ Jr (2000) Cocaine and the kidney: a synthesis of pathophysiologic and clinical perspectives. Am J Kidney Dis 35:783–795

    Article  CAS  PubMed  Google Scholar 

  79. Bachi K, Mani V, Jeyachandran D, Fayad ZA, Goldstein RZ, Alia-Klein N (2017) Vascular disease in cocaine addiction. Atherosclerosis 262:154–162

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Liu YW, Mutnuri S, Siddiqui SB, Weikle GR, Oladipo O, Ganti N, Beach RE, Afrouzian M (2016) Levamisole-adulterated cocaine nephrotoxicity: ultrastructural features. Am J Clin Pathol 145:720–726

    Article  PubMed  Google Scholar 

  81. Bohm MK, Clayton HB (2020) Nonmedical use of prescription opioids, heroin use, injection drug use, and overdose mortality in U.S. adolescents. J Stud Alcohol Drugs 81:484–488

    Article  PubMed  PubMed Central  Google Scholar 

  82. Kelley-Quon LI, Cho J, Strong DR, Miech RA, Barrington-Trimis JL, Kechter A, Leventhal AM (2019) Association of nonmedical prescription opioid use with subsequent heroin use initiation in adolescents. JAMA Pediatr 173:e191750

    Article  PubMed  PubMed Central  Google Scholar 

  83. Jaffe JA, Kimmel PL (2006) Chronic nephropathies of cocaine and heroin abuse: a critical review. Clin J Am Soc Nephrol 1:655–667

    Article  CAS  PubMed  Google Scholar 

  84. Dettmeyer R, Wessling B, Madea B (1998) Heroin associated nephropathy--a post-mortem study. Forensic Sci Int 95:109–116

    Article  CAS  PubMed  Google Scholar 

  85. Connolly JO, Gillmore JD, Lachmann HJ, Davenport A, Hawkins PN, Woolfson RG (2006) Renal amyloidosis in intravenous drug users. QJM 99:737–742

    Article  CAS  PubMed  Google Scholar 

  86. Sethi S (2018) The changing spectrum of heroin-associated kidney disease. Clin J Am Soc Nephrol 13:975–976

    Article  PubMed  PubMed Central  Google Scholar 

  87. Smith HS (2009) Opioid metabolism. Mayo Clin Proc 84:613–624

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Reis A, Luecke C, Davis TK, Kakajiwala A (2018) Pain management in pediatric chronic kidney disease. J Pediatr Pharmacol Ther 23:192–202

    PubMed  PubMed Central  Google Scholar 

  89. Davison SN (2019) Clinical pharmacology considerations in pain management in patients with advanced kidney failure. Clin J Am Soc Nephrol 14:917–931

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Nephrology, Valley Children’s Healthcare, Madera, CA, USA

    Nianzhou Xiao

  2. Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA

    Hua Chai

  3. Department of Pediatrics, Wright State University, Dayton, OH, USA

    Abiodun Omoloja

  4. Division of Nephrology, Dayton Children’s Hospital, One Children’s Plaza, Dayton, OH, 45404, USA

    Abiodun Omoloja

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  1. Nianzhou Xiao
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Xiao, N., Chai, H. & Omoloja, A. Substance use among adolescents and young adults with chronic kidney disease or kidney failure. Pediatr Nephrol 36, 3585–3593 (2021). https://doi.org/10.1007/s00467-021-05001-2

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