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An “old and new” complication in a child with nephrotic syndrome: Answers

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References

  1. Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sánchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG Jr, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G Jr, Magder LS (2012) Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64:2677–2686

    Article  Google Scholar 

  2. Andolino TP, Reid-Adam J (2003) Nephrotic syndrome. Pediatr Rev 36:117–125

    Article  Google Scholar 

  3. Orth SR, Ritz E (1998) The nephrotic syndrome. N Engl J Med 338:1202–1211

    Article  CAS  Google Scholar 

  4. Zaffanello M, Franchini M (2007) Thromboembolism in childhood nephrotic syndrome: a rare but serious complication. Hematology 12:69–73

    Article  Google Scholar 

  5. Lau SO, Tkachuck JY, Hasegawa DK, Edson JR (1980) Plasminogen and anti-thrombin III deficiencies in the childhood nephrotic syndrome associated with plasminogenuria and antithrombinuria. J Pediatr 96:390–392

    Article  CAS  Google Scholar 

  6. Lilova MI, Velkovski IG, Topalov IB (2000) Thromboembolic complications in children with nephrotic syndrome in Bulgaria (1974-1996). Pediatr Nephrol 15:74–78

    Article  CAS  Google Scholar 

  7. Citak A, Emre S, Sâirin A, Bilge I, Nayir A (2000) Hemostatic problems and thromboembolic complications in nephrotic children. Pediatr Nephrol 14:138–142

    Article  CAS  Google Scholar 

  8. Kerlin BA, Blatt NB, Fuh B, Zhao S, Lehman A, Blanchong C, Mahan JD, Smoyer WE (2009) Epidemiology and risk factors for thromboembolic complications of childhood nephrotic syndrome: a Midwest Pediatric Nephrology Consortium (MWPNC) study. J Pediatr 155:105–110

    Article  Google Scholar 

  9. Kerlin BA, Ayoob R, Smoyer WE (2012) Epidemiology and pathophysiology of nephrotic syndrome-associated thromboembolic disease. Clin J Am Soc Nephrol 7:513–520

    Article  CAS  Google Scholar 

  10. Babyn PS, Gahunia HK, Massicotte P (2005) Pulmonary thromboembolism in children. Pediatr Radiol 35:258–274

    Article  Google Scholar 

  11. Glassock RJ (2007) Prophylactic anticoagulation in nephrotic syndrome: a clinical conundrum. J Am Soc Nephrol 18:2221–2225

    Article  Google Scholar 

  12. Yokoyama H, Taguchi T, Sugiyama H, Sato H, Committee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry in the Japanese Society of Nephrology (2012) Membranous nephropathy in Japan: analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol 16:557–563

    Article  Google Scholar 

  13. Andrew M, Brooker LA (1996) Hemostatic complications in renal disorder of the young. Pediatr Nephrol 10:88–99

    Article  CAS  Google Scholar 

  14. Singhal R, Brimble KS (2006) Thromboembolic complications in the nephrotic syndrome: pathophysiology and clinical management. Thromb Res 118:397–407

    Article  CAS  Google Scholar 

  15. Barbano B, Gigante A, Amoroso A, Cianci R (2013) Thrombosis in nephrotic syndrome. Semin Thromb Hemost 39:469–476

    Article  CAS  Google Scholar 

  16. Llach F, Koffler A, Finck E (1977) On the incidence of renal vein thrombosis in the nephrotic syndrome. Arch Intern Med 137:333–336

    Article  CAS  Google Scholar 

  17. Zhang LJ, Zhang Z, Li SJ, Meinel FG, Nance JW Jr, Zhou CS, Zhao YE, Schoepf UJ, Lu GM (2014) Pulmonary embolism and renal vein thrombosis in patients with nephrotic syndrome: prospective evaluation of prevalence and risk factors with CT. Radiology 273:897–906

    Article  Google Scholar 

  18. Zhang LJ, Wang ZJ, Zhou CS, Lu L, Luo S, Lu GM (2012) Evaluation of pulmonary embolism in pediatric patients with nephrotic syndrome with dual energy CT pulmonary angiography. Acad Radiol 19:341–348

    Article  Google Scholar 

  19. Lionaki S, Derebail VK, Hogan SL, Barbour S, Lee T, Hladunewich M, Greenwald A, Hu Y, Jennette CE, Jennette JC, Falk RJ, Cattran DC, Nachman PH, Reich HN (2012) Venous thromboembolism in patients with membranous nephropathy. Clin J Am Soc Nephrol 7:43–51

    Article  CAS  Google Scholar 

  20. Yang Y, Lv J, Zhou F, Chen M, Wang R, Zhao M, Wang H (2014) Risk factors of pulmonary thrombosis/embolism in nephrotic syndrome. Am J Med Sci 348:394–398

    Article  Google Scholar 

  21. Braun B, Weilemann LS, Weigand W (1981) Ultrasonic demonstration of renal vein thrombosis. Radiology 138:157–158

    Article  CAS  Google Scholar 

  22. Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH, Somers MJ, Trachtman H, Waldman M (2013) KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis. Am J Kidney Dis 62:403–441

    Article  Google Scholar 

  23. Medjeral-Thomas N, Ziaj S, Condon M, Galliford J, Levy J, Cairns T, Griffith M (2014) Retrospective analysis of a novel regimen for the prevention of venous thromboembolism in nephrotic syndrome. Clin J Am Soc Nephrol 9:478–483

    Article  Google Scholar 

  24. Kelddal S, Nykjær KM, Gregersen JW, Birn H (2019) Prophylactic anticoagulation in nephrotic syndrome prevents thromboembolic complications. BMC Nephrol 20:139

    Article  Google Scholar 

  25. Brodsky SV, Satoskar A, Chen J, Nadasdy G, Eagen JW, Hamirani M, Hebert L, Calomeni E, Nadasdy T (2009) Acute kidney injury during warfarin therapy associated with obstructive tubular red blood cell casts: a report of 9 cases. Am J Kidney Dis 54:1121–1126

    Article  Google Scholar 

  26. Brodsky SV, Nadasdy T, Rovin BH, Satoskar AA, Nadasdy GM, Wu HM, Bhatt UY, Hebert LA (2011) Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate. Kidney Int 80:181–189

    Article  CAS  Google Scholar 

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Correspondence to Hiroshi Kaito.

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Inaguma, Y., Kaito, H., Horinouchi, T. et al. An “old and new” complication in a child with nephrotic syndrome: Answers. Pediatr Nephrol 36, 1955–1958 (2021). https://doi.org/10.1007/s00467-020-04794-y

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