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Metabolic programming of nephron progenitor cell fate

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Abstract

Metabolic pathways are one of the first responses at the cellular level to maternal/fetal interface stressors. Studies have revealed the previously unrecognized contributions of intermediary metabolism to developmental programs. Here, we provide an overview of cellular metabolic pathways and the cues that modulate metabolic states. We discuss the developmental and physiological implications of metabolic reprogramming and the key role of metabolites in epigenetic and epiproteomic modifications during embryonic development and with respect to kidney development and nephrogenesis.

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Abbreviations

α-KG:

Alpha ketoglutarate

CAKUT:

Congenital abnormalities of kidney and urinary tract

CM:

Cap mesenchyme

CKD:

Chronic kidney disease

CVD:

Cardiovascular disease

ESC:

Embryonic stem cell

FAD:

Flavin adenine dinucleotide

GFR:

Glomerular filtration rate

HBP:

Hexosamine biosynthesis pathway

HSPG:

Heparan sulfate proteoglycans

JmjC:

Jumonji C-domain containing protein family of demethylases

LSD:

Lysine-specific demethylase

MM:

Metanephric mesenchyme

MPC1/2:

Mitochondrial pyruvate carrier

NAD:

Nicotinamide adenine dinucleotide

NPC:

Nephron progenitor cells

PFKFB3:

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase

PPP:

Pentose phosphate pathway

PSC:

Pluripotent stem cells

PTM:

Posttranslational modification

RTK:

Receptor tyrosine kinase

SAM:

S-Adenosyl methionine

TCA:

Tricarboxylic acid cycle

UB:

Ureteric bud

VHL:

Von Hippel–Lindau tumor suppressor

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Acknowledgments

The authors thank Dr. Samir El-Dahr for his critical reading of this review and suggestions.

Funding

Z. S. is funded by the NIH grant DK118231.

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  1. Department of Pediatrics, Tulane University School of Medicine, 1430 Tulane Avenue SL37, Room 5534, New Orleans, LA, 70112, USA

    Giovane G Tortelote, Mariel Colón-Leyva & Zubaida Saifudeen

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Tortelote, G.G., Colón-Leyva, M. & Saifudeen, Z. Metabolic programming of nephron progenitor cell fate. Pediatr Nephrol 36, 2155–2164 (2021). https://doi.org/10.1007/s00467-020-04752-8

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