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Case summary
A 7-year-old girl who had been followed up with cerebral palsy and epilepsy was consulted to our pediatric nephrology outpatient clinic because of incidentally detected hyponatremia on routine follow-up. She had birth-adjusted cerebral palsy and received various antiepileptics since the newborn period.
She had been on treatment with valproic acid and clonazepam for 1 year and 3 months prior to her referral and the dosage of valproic acid had been increased to 40 mg/kg/daily because of short-lasting intractable seizures.
At admission, her vital signs were normal; she had no signs of dehydration or hypovolemia. Neurological examination revealed increased deep tendon reflexes and Babinski reflex. Other systemic examination findings were normal.
Laboratory investigations were as follows: glucose 94 mg/dl (74–106), creatinine 0.27 mg/dl (0.3–0.7), urea 17 mg/dl (11–38), sodium 129 mEq/L (135–145), potassium 4.83 mEq/L (4.1–5.3), calcium 9.21 mg/dl (8.5–10), phosphorus 4.5 mg/dl (4.5–5.5), chloride 99 mEq/L (98–107), magnesium 1.88 mg/dl (1.5–2.3), aspartate aminotransferase 35.7 IU/L (15–60), alanin aminotransferase 10.5 IU/L (0–35), and uric acid 2 mg/dl (2.6–6 ). Thyroid function tests were normal. Blood gas analysis revealed a pH of 7.44, HCO3 of 22.9, and pCO2 of 27.3. Serum level of valproic acid was 142 micgr/ml (theraupetic range 50–100 micgr/ml). Urine sodium was 41 mEq/L, potassium was 15 mEq/L, and density was 1025; urine microscopic examination was normal. Plasma osmolality was 269 mOsm/kg and urine osmolality was 280 mOsm/kg. Ultrasonographic examination of kidneys and the urinary tract was normal. Cranial computerized tomography was normal except for chronic alterations due to perinatal asphyxia.
Questions
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What is your diagnosis for this patient?
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What is the underlying etiology of this disorder?
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What is the best management strategy for this patient?
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The answers to these questions can be found at https://doi.org/10.1007/s00467-020-04649-6.
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Özlü, S.G., Özdemir, S.İ., Kılıc, D. et al. An uncommon cause of a common disorder: Questions. Pediatr Nephrol 36, 1133 (2021). https://doi.org/10.1007/s00467-020-04642-z
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DOI: https://doi.org/10.1007/s00467-020-04642-z