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Neurophysiological control of urinary bladder storage and voiding—functional changes through development and pathology

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Abstract

The effective storage of urine and its expulsion relies upon the coordinated activity of parasympathetic, sympathetic, and somatic innervations to the lower urinary tract (LUT). At birth, all mammalian neonates lack the ability to voluntary regulate bladder storage or voiding. The ability to control urinary bladder activity is established as connections to the central nervous system (CNS) form through development. The neural regulation of the LUT has been predominantly investigated in adult animal models where comparatively less is known about the neonatal and postnatal neurophysiological development that facilitate urinary continence. Furthermore, congenital neurological or anatomical defects can adversely affect both storage and voiding functions through postnatal development and into adulthood, leading to secondary conditions including vesicoureteral reflux, chronic urinary tract infections, and end-stage renal disease. Therefore, the aim of the review is to provide the current knowledge available on neurophysiological regulation of the LUT through pre- to postnatal development of human and animal models and the consequences of congenital anomalies that can affect LUT neural function.

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Funding

This work was funded by a Department of Defense grant (W81XWH1810436) to A.Kanai and Y.Ikeda.

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  1. School of Medicine, Renal-Electrolyte Division, University of Pittsburgh, A1219 Scaife Hall, Pittsburgh, PA, 15261, USA

    Youko Ikeda

  2. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA

    Youko Ikeda

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  1. Youko Ikeda
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Correspondence to Youko Ikeda.

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Ikeda, Y. Neurophysiological control of urinary bladder storage and voiding—functional changes through development and pathology. Pediatr Nephrol 36, 1041–1052 (2021). https://doi.org/10.1007/s00467-020-04594-4

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  • DOI: https://doi.org/10.1007/s00467-020-04594-4

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