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Hyperprolactinemia as a prognostic factor for menstrual disorders in female adolescents with advanced chronic kidney disease

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Abstract

Background

In adolescents with chronic kidney disease (CKD), menstrual disorders (MD) are common, which can make the management of CKD difficult and can sometimes delay renal transplantation. This study aimed to identify the usefulness of hormonal measurements in adolescents with CKD and their relationships with MD during a 1-year follow-up.

Methods

A prospective cohort study was designed. Adolescents with CKD stages IV and V were included. Through clinical files and via interview, the ages at puberty onset, menarche and the date of last menstruation were identified. A 1-year follow-up was conducted over a menstrual cycle calendar. At the beginning of follow-up, routine hormonal profiles (thyroid profiles, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol) were assessed. We compared the hormonal profiles of the patients with and without MD (wMD vs. woMD). Comparisons between groups were made by Wilcoxon and Fisher’s tests. Logistic regression analysis was used.

Results

Fifty-seven patients, including 30 patients classified as wMD, were analyzed. The median age was 15 years, and the median time of CKD evolution was 18 months. There were no differences in general and biochemical characteristics between patients wMD and woMD. In terms of hormonal measurements, the levels of thyroid-stimulating hormone (TSH) and prolactin were higher in the wMD patients. A prolactin level ≥ 36.8 ng/ml was a risk factor for presenting with MD (RR 34.4, p = 0.002).

Conclusions

Hyperprolactinemia is correlated with MD in adolescents with CKD.

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Financial support

This work was supported by a Mexican Federal Funds Grant (HIM 2017/131).

Author information

Authors and Affiliations

  1. Adolescent Medicine Service, Hospital Infantil de México Federico Gómez, Ministry of Health (SSA), Mexico City, Mexico

    Juana Serret-Montaya & Jessie N. Zurita-Cruz

  2. Unit of Nutrition, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Mexico City, Mexico

    Jessie N. Zurita-Cruz

  3. Research Unit in Analysis and Synthesis of the Evidence, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Mexico City, Mexico

    Miguel A. Villasís-Keever

  4. Department of Pediatric Nephology, Children’s Hospital, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Mexico City, Mexico

    Alejandra Aguilar-Kitsu, Claudia del Carmen Zepeda-Martinez, Irving Cruz-Anleu, Beatriz C. Hernández-Hernández & Sara R. Alonso-Flores

  5. Endocrine Research Unit, Centro Médico Nacional, Instituto Mexicano del Seguro Social, Mexico City, Mexico

    Leticia Manuel-Apolinar & Leticia Damasio-Santana

  6. Department of Pediatric Gynecology, Children’s Hospital, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Mexico City, Mexico

    Abigail Hernandez-Cabezza

  7. Department of Pediatric Nephology, Hospital Infantil de México Federico Gómez, Ministry of Health (SSA), Mexico City, Mexico

    José C. Romo-Vázquez

Authors
  1. Juana Serret-Montaya
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  2. Jessie N. Zurita-Cruz
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  3. Miguel A. Villasís-Keever
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  8. Sara R. Alonso-Flores
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  9. Leticia Manuel-Apolinar
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  12. José C. Romo-Vázquez
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Contributions

Juana Serret-Montoya: Contribution in the conception, study design, data collection, analysis of data, and drafting of the article. Approval of the final version of the manuscript

Jessie Zurita-Cruz: Study design, data collection, analysis of data, drafting of the article, and writing and critical review of the article content. Approval of the final version of the manuscript

Miguel A. Villasis-Keever: Writing and critical review of the article content. Approval of the final version of the manuscript

Alejandra Aguilar-Kitsu: Writing and critical review of the article content. Approval of the final version of the manuscript

Claudia Del Carmen Zepeda-Martinez: Data collection, writing and critical review of the article content. Approval of the final version of the manuscript

Irving Cruz-Anleu: Data collection, writing and critical review of the article content. Approval of the final version of the manuscript

Beatriz Carolina Hernández-Hernández: Data collection, writing and critical review of the article content. Approval of the final version of the manuscript

Sara Reyna Alonso-Flores: Data collection, writing and critical review of the article content. Approval of the final version of the manuscript

Leticia Manuel-Apolinar: Data collection. Writing and critical review of the article content. Approval of the final version of the manuscript

Leticia Damasio-Santana: Data collection. Writing and critical review of the article content. Approval of the final version of the manuscript

Abigail Hernandez-Cabezza: Writing and critical review of the article content. Approval of the final version of the manuscript

Dr. José Carlos Romo-Vázquez: Writing and critical review of the article content. Approval of the final version of the manuscript

Corresponding author

Correspondence to Jessie N. Zurita-Cruz.

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The authors declare no conflicts of interest.

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Serret-Montaya, J., Zurita-Cruz, J.N., Villasís-Keever, M.A. et al. Hyperprolactinemia as a prognostic factor for menstrual disorders in female adolescents with advanced chronic kidney disease. Pediatr Nephrol 35, 1041–1049 (2020). https://doi.org/10.1007/s00467-020-04494-7

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  • DOI: https://doi.org/10.1007/s00467-020-04494-7

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