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New insights into the pathogenesis of Streptococcus pneumoniae–associated hemolytic uremic syndrome

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Abstract

The purpose of this review is to describe Streptococcus pneumoniae–associated hemolytic uremic syndrome (P-HUS) with emphasis on new insights into the pathophysiology and management over the past 10 years. Even though awareness of this clinico-pathological entity has increased, it likely remains under-recognized. Recent observations indicate that although neuraminidase activity and exposure of the T-antigen are necessary for development of P-HUS, they are not sufficient; activation of the alternate pathway of complement may also contribute. It is unclear, however, whether or not eculizumab and/or plasmapheresis are of value.

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  1. Division of Nephrology, Department of Pediatrics, The Children’s Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA

    Rebecca R. Scobell, Bernard S. Kaplan & Lawrence Copelovitch

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Scobell, R.R., Kaplan, B.S. & Copelovitch, L. New insights into the pathogenesis of Streptococcus pneumoniae–associated hemolytic uremic syndrome. Pediatr Nephrol 35, 1585–1591 (2020). https://doi.org/10.1007/s00467-019-04342-3

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