Pediatric Nephrology

, Volume 32, Issue 5, pp 897–900 | Cite as

Does Zika virus infection induce prolonged remissions in children with idiopathic nephrotic syndrome?

Brief Report

Abstract

Background

Zika is an emerging mosquito-borne flavivirus. We report two pediatric patients diagnosed with idiopathic nephrotic syndrome who achieved complete remission of the disease after suffering Zika virus (ZIKV) infection.

Case Diagnosis/Treatment

The first patient was a young girl aged 2.5 years with steroid-dependent nephrotic syndrome who was subsequently diagnosed with ZIKV infection. Following the infection, the steroid dose could be reduced until complete withdrawal. The patient persists in complete remission. The second patient was a steroid-resistant boy aged 7 years who was scheduled for a renal biopsy when he was diagnosed with ZIKV infection. A week after the recovery phase of the acute rash, proteinuria was noted to be gradually falling. Today, 12 months later, he is in complete remission of the disease.

Conclusions

We are aware that the improvement observed in our two patients after ZIKV infection may be be random. However, it is also possible that future studies will discover that ZIKV infection has some effect on the cellular immune system similar to that of measles infection.

Keywords

Idiopathic nephrotic syndrome Zika virus infection Viral infections Flavivirus 

References

  1. 1.
    Block WM, Jackson RL, Stearns G, Butsch MP (1948) Lipoid nephrosis; clinical and biochemical studies of 40 children, with 10 necropsies. Pediatrics 1:733–753PubMedGoogle Scholar
  2. 2.
    Aldrich CA (1926) Treatment of nephrosis. Am J Dis Child 32:163CrossRefGoogle Scholar
  3. 3.
    Heymann W, Startzman V (1946) Lipemic nephrosis. J Pediatr 28:117–133CrossRefPubMedGoogle Scholar
  4. 4.
    Blumberg RW, Cassady HA (1947) Effect of measles on the nephrotic syndrome. Am J Dis Child 73:151–166PubMedGoogle Scholar
  5. 5.
    Meizlik EH, Carpenter AM (1948) Beneficial effect of measles on nephrosis; report of three cases. Am J Dis Child 76:83–90CrossRefPubMedGoogle Scholar
  6. 6.
    Rosenblum, Lander HB, Fisher RM (1949) Measles in the nephrotic syndrome. J Pediatr 35:574–584CrossRefPubMedGoogle Scholar
  7. 7.
    Hutchins G, Janeway CA (1947) Observations on the relationship of measles and remissions in the nephrotic syndrome. Am J Dis Child 73:242PubMedGoogle Scholar
  8. 8.
    Janeway CA, Moll GH, Armstrong SH Jr, Wallace WM, Hallman N, Barness LA (1948) Diuresis in children with nephrosis. Comparison of response to injection of normal human serum albumin and to infection, particularly measles. Trans Assoc Am Physicians 61:108–111Google Scholar
  9. 9.
    Byrne EA (1952) Malarial therapy in lipoid nephrosis. Lancet 1:844–845CrossRefPubMedGoogle Scholar
  10. 10.
    Barnett HL, McNamara H, McCrory W, Forman C, Rapoport M, Michie A, Barbero G (1950) The effects of ACTH and cortisone on the nephrotic syndrome. AMA Am J Dis Child 80:519–520PubMedGoogle Scholar
  11. 11.
    Rapoport M, McCrory W, Michie AJ, Barbero G, Barnett HL, Forman CW, McNamara H (1951) Effects of corticotrophin on children with nephrotic syndrome: clinical observations on 34 children; the effect of cortisone in 4. AMA Am J Dis Child 82:248–253PubMedGoogle Scholar
  12. 12.
    Taylor RD, Corcoran AC, Page IH (1950) Treatment of the nephrotic syndrome with nitrogen mustard. J Lab Clin Med 36:996–997PubMedGoogle Scholar
  13. 13.
    Kelley VC, Panos TC (1952) The nephrotic syndrome in children. I. Clinical response to nitrogen mustard therapy. J Pediatr 41:505–517CrossRefPubMedGoogle Scholar
  14. 14.
    Takahashi S, Wada N, Murakami H, Funaki S, Inagaki T, Harada K, Nagata M (2007) Triggers of relapse in steroid-dependent and frequently relapsing nephritic syndrome. Pediatr Nephrol 22:232–236CrossRefPubMedGoogle Scholar
  15. 15.
    Lagrue G, Xheneumont S, Branellec A, Hirbec G, Weil B (1975) A vascular permeability factor elaborated from lymphocytes. I. Demonstration in patients with nephrotic syndrome. Biomedicine 23:37–40PubMedGoogle Scholar
  16. 16.
    Maruyama K, Tomizawa S, Shimabukuro N, Fukuda T, Johshita T, Kuroume T (1989) Effect of supernatants derived from T lymphocyte culture in minimal change nephritic syndrome on rat kidney capillaries. Nephron 51:73–76CrossRefPubMedGoogle Scholar
  17. 17.
    Garin EH, Blanchard DK, Matsushima K, Djeu JY (1994) IL-8 production by peripheral blood mononuclear cells in nephrotic patients. Kidney Int 45:1311–1317CrossRefPubMedGoogle Scholar
  18. 18.
    Kemper MJ, Meyer-Jark T, Lilova M, Müller-Wiefel DE (2003) Combined T- and B-cell activation in childhood steroid-sensitive nephrotic syndrome. Clin Nephrol 60:242–247CrossRefPubMedGoogle Scholar
  19. 19.
    von Pirquet C (1908) Das verhalten der kutanen tuberkulin-reaktion wahrend der masern. Dtsch Med Wochenschr 34:1297–1300CrossRefGoogle Scholar
  20. 20.
    Finkel A, Dent PB (1973) Virus-leukocyte interactions: relationship to host resistance in virus infections in man. Pathobiol Ann 3:47–70Google Scholar
  21. 21.
    Fireman P, Friday G, Kumate J (1969) Effect of measles vaccine on immunologic responsiveness. Pediatrics 43:264–272PubMedGoogle Scholar
  22. 22.
    Zweiman B, Pappagianis D, Maibach H, Hildreth EH (1971) Effect of measles immunization on tuberculin hypersensitivity and in vitro lymphocyte reactivity. Int Arch Allergy Appl Immunol 40:834–841CrossRefPubMedGoogle Scholar
  23. 23.
    Sullivan JL, Barry DW, Albrecht P, Lucas SJ (1975) Inhibition of lymphocyte stimulation by measles virus. J Immunol 114:1458–1461PubMedGoogle Scholar
  24. 24.
    McFarland HF (1974) The effect of measles virus infection of T and B lymphocytes in the mouse. I. Suppression of helper cell activity. J Immunol 113:1978–1983PubMedGoogle Scholar
  25. 25.
    Whittle HC, Dossetor J, Oduloju A, Bryceson AD, Greenwood BM (1978) Cell mediated immunity during natural measles infection. J Clin Invest 62:678–684CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Fujinami RS, Sun X, Howell JM, Jenkin JC, Burns JB (1998) Modulation of immune system function by measles virus infection: role of soluble factor and direct infection. J Virol 72:9421–9427PubMedPubMedCentralGoogle Scholar
  27. 27.
    Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C (2000) Consequences of fas-mediated human dendritic cell apoptosis induced by measles virus. J Virol 74:4387–4393CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Auwaerter PG, Kaneshima H, McCune JM, Wiegand G, Griffin DE (1996) Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis. J Virol 70:3734–3740PubMedPubMedCentralGoogle Scholar
  29. 29.
    Griffin DE, Ward BJ, Jauregui E, Johnson RT, Vaisberg A (1990) Natural killer cell activity during measles. Clin Exp Immunol 81:218–224CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Griffin DE, Ward BJ (1993) Differential CD4 T cell activation in measles. J Infect Dis 168:275–281CrossRefPubMedGoogle Scholar
  31. 31.
    Atabani SF, Byrnes AA, Jaye A, Kidd IM, Magnusen AF, Whittle H, Karp CL (2001) Natural measles causes prolonged suppression of interleukin-12 production. J Infect Dis 184:1–9CrossRefPubMedGoogle Scholar
  32. 32.
    Sun X, Burns JB, Howell JM, Fujinami RS (1998) Suppression of antigen-specific T cell proliferation by measles virus infection: role of a soluble factor in suppression. Virology 246:24–33CrossRefPubMedGoogle Scholar
  33. 33.
    Ioos S, Mallet HP, Leparc Goffart I, Gauthier V, Cardoso T, Herida M (2014) Current Zika virus epidemiology and recent epidemics. Med Mal Infect 44:302–307CrossRefPubMedGoogle Scholar
  34. 34.
    Tappe D, Pérez-Girón JV, Zammarchi L, Rissland J, Ferreira DF, Jaenisch T, Gómez-Medina S, Günther S, Bartoloni A, Muñoz-Fontela C, Schmidt-Chanasit J (2016) Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase. Med Microbiol Immunol 205:269–273CrossRefPubMedGoogle Scholar
  35. 35.
    Ferreira da Silva IR, Frontera JA, Moreira do Nascimento OJ (2016) News from the battlefront: Zika virus-associated Guillain-Barré syndrome in Brazil. Neurology 87:e180–e181CrossRefPubMedGoogle Scholar
  36. 36.
    Lucchese G, Kanduc D (2016) Zika virus and autoimmunity: from microcephaly to Guillain-Barré syndrome, and beyond. Autoimmun Rev 15:801–808CrossRefPubMedGoogle Scholar

Copyright information

© IPNA 2017

Authors and Affiliations

  1. 1.Hospital UyaparPuerto OrdazVenezuela
  2. 2.Pediatric Nephrology ServiceHospital Nuestra Señora de CandelariaSanta Cruz de TenerifeSpain

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