Pediatric Nephrology

, Volume 32, Issue 5, pp 897–900 | Cite as

Does Zika virus infection induce prolonged remissions in children with idiopathic nephrotic syndrome?

  • Carolina Peralta-Aros
  • Víctor García-Nieto
Brief Report



Zika is an emerging mosquito-borne flavivirus. We report two pediatric patients diagnosed with idiopathic nephrotic syndrome who achieved complete remission of the disease after suffering Zika virus (ZIKV) infection.

Case Diagnosis/Treatment

The first patient was a young girl aged 2.5 years with steroid-dependent nephrotic syndrome who was subsequently diagnosed with ZIKV infection. Following the infection, the steroid dose could be reduced until complete withdrawal. The patient persists in complete remission. The second patient was a steroid-resistant boy aged 7 years who was scheduled for a renal biopsy when he was diagnosed with ZIKV infection. A week after the recovery phase of the acute rash, proteinuria was noted to be gradually falling. Today, 12 months later, he is in complete remission of the disease.


We are aware that the improvement observed in our two patients after ZIKV infection may be be random. However, it is also possible that future studies will discover that ZIKV infection has some effect on the cellular immune system similar to that of measles infection.


Idiopathic nephrotic syndrome Zika virus infection Viral infections Flavivirus 


Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© IPNA 2017

Authors and Affiliations

  1. 1.Hospital UyaparPuerto OrdazVenezuela
  2. 2.Pediatric Nephrology ServiceHospital Nuestra Señora de CandelariaSanta Cruz de TenerifeSpain

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