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Long-term health-related quality of life and psychological adjustment in children after haemolytic-uraemic syndrome

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Abstract

Background

In children after haemolytic-uraemic syndrome (HUS), little is known about long-term health-related quality of life (HRQoL) and psychological adjustment as defined by behavioural problems, depressive symptoms and post-traumatic stress symptoms.

Methods

Sixty-two paediatric patients with a history of HUS were included in this study. Medical data of the acute HUS episode were retrieved retrospectively from hospital records. Data on the clinical course at study investigation were assessed by clinical examination and laboratory evaluation. HRQoL and psychological adjustment data were measured by standardised, parent- and self-reported questionnaires.

Results

Haemolytic-uraemic syndrome was diagnosed at a mean of 6.5 years before the initiation of the study (standard deviation 2.9, range 0.1–15.7) years. Among the preschool children, parents reported that their child was less lively and energetic (HRQoL emotional dimension), while no increased behavioural problems were reported. In the school-age children, self- and proxy-reported HRQoL was well within or even above the norms, while increased total behavioural problems were found. The school-age children reported no increased depression scores. Also none of the children met the criteria for full or partial HUS-associated posttraumatic stress disorder.

Conclusions

Healthcare providers should be particularly alert to behavioural problems in school-age children with a history of HUS and to lower HRQoL in preschool children.

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Author information

Authors and Affiliations

  1. Department of Psychosomatics and Psychiatry, University Children’s Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland

    Helene Werner & Markus A. Landolt

  2. Division of Child and Adolescent Health Psychology, Department of Psychology, University of Zurich, Binzmuehlestrasse 14, 8051, Zurich, Switzerland

    Helene Werner & Markus A. Landolt

  3. Paediatric Nephrology Unit, University Children’s Hospital Zurich, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland

    Kathrin Buder, Guido F. Laube & Giuseppina Spartà

  4. Children’s Hospital of Lucerne, Cantonal Hospital of Lucerne, 6000, Lucerne 16, Switzerland

    Thomas J. Neuhaus

Authors
  1. Helene Werner
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  2. Kathrin Buder
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  3. Markus A. Landolt
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  4. Thomas J. Neuhaus
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  5. Guido F. Laube
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  6. Giuseppina Spartà
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Corresponding author

Correspondence to Giuseppina Spartà.

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Funding sources

The study was supported by the “Erika Bär-Spycher” Foundation and by the “Kinder für Kinder” Foundation.

Conflict of interest

The authors declare that there is no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Additional information

H.W. and K.B. contributed equally to this article.

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Werner, H., Buder, K., Landolt, M.A. et al. Long-term health-related quality of life and psychological adjustment in children after haemolytic-uraemic syndrome. Pediatr Nephrol 32, 869–878 (2017). https://doi.org/10.1007/s00467-016-3569-0

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  • DOI: https://doi.org/10.1007/s00467-016-3569-0

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