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Urinary markers in the early stage of nephropathy in patients with childhood-onset type 1 diabetes

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Abstract

Background

The aim of this study was to evaluate the association of a urinary tubular marker, liver-type fatty acid binding protein (L-FABP) and an inflammatory marker, serum/urinary YKL-40, with albuminuria in patients with childhood-onset type 1 diabetes (T1D).

Methods

Twenty-nine patients with childhood-onset T1D and 32 controls were enrolled. Serum and urinary concentrations of YKL-40 and urinary concentrations of L-FABP were measured.

Results

The serum levels of YKL-40 were not significantly different between the control group and the patient groups. However, the levels of urinary YKL-40/creatinine (Cr) were higher in the patients, even those with normoalbuminuria than in the controls (p < 0.001). The levels of urinary L-FABP/Cr were not different between the control group and the patient groups. However, the level of urinary L-FABP/Cr in the microalbuminuria group was higher than that in the normoalbuminuria group (p = 0.03). There were no associations between the levels of urinary albumin-to-creatinine ratio and urinary L-FABP/Cr or YKL-40/Cr. However, the urinary L-FABP/Cr level was significantly correlated with the hemoglobin A1C level (p = 0.005) and the urinary YKL-40/Cr level (p = 0.043).

Conclusions

Urinary L-FABP/Cr and YKL-40/Cr may reflect renal injury in early stages of nephropathy in patients with childhood-onset T1D, even in the normoalbuminuric state.

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Acknowledgments

This research was partly supported by the Institute of Clinical Medicine Research of Bucheon St. Mary’s Hospital, Research Fund, BCMC13YH9.

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Correspondence to Min Ho Jung.

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This study was approved by the institutional review board of the Catholic University of Korea and written informed consent was obtained from all study participants and the caregivers of each child before enrollment.

Conflict of interest

The author(s) declare that they have no competing interests.

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Suh, JS., Kim, SH., Cho, K.S. et al. Urinary markers in the early stage of nephropathy in patients with childhood-onset type 1 diabetes. Pediatr Nephrol 31, 623–631 (2016). https://doi.org/10.1007/s00467-015-3253-9

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  • DOI: https://doi.org/10.1007/s00467-015-3253-9

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