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Effect of plasma NOx values on cardiac function in obese hypertensive and normotensive pediatric patients

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Abstract

Background

Hypertension (HT) is a major comorbidity of obesity that is associated with an increased risk of cardiovascular disease and higher mortality. The aim of our study was to evaluate cardiac function in obese hypertensive (OHT) and obese normotensive (ONT) pediatric patients and determine the effects of plasma nitric oxide (NOx) values on cardiac function, while demonstrating the role of plasma NOx in HT in obese pediatric patients.

Methods

The study population consisted of 62 patients (27 boys, 35 girls), aged 13–18 years and 21 age-matched healthy controls. All subjects enrolled in the study underwent echocardiography (Echo) evaluation and ambulatory blood pressure monitoring for HT. Plasma NOx and biochemical values were studied in both patient groups separately.

Results

Plasma NOx levels were found to be lower in the OHT group than in the ONT and control groups (p < 0.001) and to be negatively correlated with left ventricular mass index values (p < 0.05). Both the OHT and ONT groups had concentric hypertrophy of the heart.

Conclusions

Plasma NOx plays an essential role in obesity-induced HT. Concentric hypertrophy of the left ventricle was found in both the OHT and ONT groups, indicating structural deformation of the heart.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Gazi University School of Medicine, Konya yolu, 06500, Besevler, Ankara, Turkey

    Meltem Akcaboy & Necla Buyan

  2. Department of Pediatric Cardiology, Gazi University School of Medicine, Ankara, Turkey

    Serdar Kula & Semiha Terlemez

  3. Department of Physiology, Gazi University School of Medicine, Ankara, Turkey

    Tayfun Göktas

  4. Department of Neurology, Gazi University School of Medicine, Ankara, Turkey

    Bijen Nazlıel

  5. Department of Pediatric Endocrinology, Gazi University School of Medicine, Ankara, Turkey

    Nurullah Celik

  6. Faculty of Science, Department of Biostatistics, Gazi University, Ankara, Turkey

    Bülent Celik

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  1. Meltem Akcaboy
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  2. Serdar Kula
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Correspondence to Meltem Akcaboy.

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The authors declare that they have no conflict of interest.

Ethical statement

The study adhered to the principles of the Declaration of Helsinki and was approved by the local Ethics Committee (Date: 27 April 2011; Protocol Number: 105). Written informed consent was obtained from all patients enrolled in the study and also from all control subjects and their parents.

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Akcaboy, M., Kula, S., Göktas, T. et al. Effect of plasma NOx values on cardiac function in obese hypertensive and normotensive pediatric patients. Pediatr Nephrol 31, 473–483 (2016). https://doi.org/10.1007/s00467-015-3223-2

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  • DOI: https://doi.org/10.1007/s00467-015-3223-2

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