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Toxic environmental exposures and kidney health in children

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Abstract

High-level exposures to a number of agents are known to have direct nephrotoxic effects in children. A growing body of literature supports the hypothesis that chronic, relatively low-level exposure to various nephrotoxicants may also increase the risk for chronic kidney disease (CKD) or accelerate its progression. In this review we highlight several environmental nephrotoxicants and their association with CKD in children and adolescents. We also discuss unique epidemiological challenges in the use of kidney biomarkers in environmental nephrotoxicology.

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Authors and Affiliations

  1. Division of Pediatric Nephrology, Children’s Mercy Hospital, 2401 Gillham Rd, Kansas City, MO, 64108, USA

    Darcy K. Weidemann

  2. Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Virginia M. Weaver

  3. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Virginia M. Weaver & Jeffrey J. Fadrowski

  4. Division of Nephrology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Jeffrey J. Fadrowski

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  1. Darcy K. Weidemann
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  2. Virginia M. Weaver
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Correspondence to Darcy K. Weidemann.

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Weidemann, D.K., Weaver, V.M. & Fadrowski, J.J. Toxic environmental exposures and kidney health in children. Pediatr Nephrol 31, 2043–2054 (2016). https://doi.org/10.1007/s00467-015-3222-3

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