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Sleep-disordered breathing in children with chronic kidney disease

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Abstract

Background

The aim of our study was to ascertain the prevalence and type of sleep-disordered breathing (SDB) in paediatric patients with severe chronic kidney disease (CKD) based on the results of polysomnograms (PSGs).

Methods

Overnight PSGs were conducted on children with CKD stages 3–5 (dialysis dependent). Data were collected on patient demographics from the medical records. Study participants and/or their caregivers completed the paediatric modification of the Epworth Sleepiness Scale Score, the Pediatric Sleep Questionnaire (PSQ) and the Pediatric Quality of Life Inventory at the time of the PSG.

Results

Nineteen children were included in the study, of whom seven were on dialysis. The median (interquartile range) age at the time of the PSG was 13.5 (5.4–16.5) years, and eight (42 %) of the children were male. There was a 37 % (n = 7) prevalence of SDB in this cohort based on the PSG results. Central sleep apnea and obstructive sleep apnea were found in three children each. The PSQ scores did not correlate with the obstructive apnea–hypopnea index.

Conclusions

There was a high prevalence of SDB in this cohort of children with CKD. The PSG and validated sleep questionnaires yielded discordant results, reinforcing the limitations of diagnosing SDB in the CKD population based solely on sleep questionnaires.

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Acknowledgements

The authors would like to acknowledge Colin Massicotte for his help with scoring of the polysomnograms and Nicole Sidhu for her help with data management. We would also like to thank the nephrology clinic for their help with patient recruitment as well as the cooperation of all of the patients and their families who participated in this study.

Conflict of interest

The authors have no conflicts of interests to declare.

Funding source(s) disclosure

This work was supported by a Paediatric Consultants grant from the Hospital for Sick Children, Toronto, Canada. The authors have no relevant funding disclosures

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Authors and Affiliations

  1. Division of Respiratory Medicine, The Hospital for Sick Children, 4539 Hill Wing, 555 University Avenue, Toronto, ON, M5G 1X8, Canada

    Reshma Amin, Neha Sharma, Priya Sayal & Suhail Al-Saleh

  2. Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Reshma Amin, Neha Sharma, Suhail Al-Saleh, Indra Narang & Elizabeth Harvey

  3. Department of Child Health and Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada

    Reshma Amin

  4. Department of Paediatric Nephrology, King Abdulaziz Medical City, Riyadh, Saudi Arabia

    Khamisa Al-Mokali

  5. Department of Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada

    Suhail Al-Saleh & Indra Narang

  6. Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    Elizabeth Harvey

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  1. Reshma Amin
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Correspondence to Reshma Amin.

Additional information

This work has been presented in abstract form at the Canadian Respiratory Conference 2014 and at the American Academy of Sleep Medicine 2014 Conference.

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Amin, R., Sharma, N., Al-Mokali, K. et al. Sleep-disordered breathing in children with chronic kidney disease. Pediatr Nephrol 30, 2135–2143 (2015). https://doi.org/10.1007/s00467-015-3155-x

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  • DOI: https://doi.org/10.1007/s00467-015-3155-x

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