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Urinary excretion of polyols and sugars in children with chronic kidney disease

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Abstract

Background

The urinary concentrations of monosaccharides and polyols are used for diagnosing inborn errors of metabolism and renal tubular disorders. Reference values are age-related and depend on the method of detection. However, the influence of the renal function is often still neglected. In this study we examined the urinary excretion of monosaccharides and polyols in children with various degrees of chronic kidney disease (CKD), but with no known metabolic or renal tubular disorders.

Case diagnosis/treatment

In 25 patients with CKD stage 1–5, urinary concentrations of 18 monosaccharides and polyols were measured by gas chromatography–mass spectrometry (GC-MS) in random urinary samples and were compared with age-related reference values. Serum creatinine was measured at the time of the urine sample, and the height-independent estimated glomerular filtration rate (eGFR-Pottel) was calculated. Urinary excretions of monosaccharides and polyols were above the reference values in 8–88 % of all patients. A significant difference between CKD stage 1–2 compared with CKD stage 3–5 was found for allose, arabitol and sorbitol (p < 0.05) and for arabinose, fucose, myoinositol, ribitol, xylitol, and xylose (p < 0.01).

Conclusions

We show that the excretion of polyols and sugars depends on eGFR, which warrants a cautious interpretation of the results in patients with CKD.

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Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Pediatric Nephrology & Growth and Regeneration, University Hospitals Leuven & Katholieke Universiteit Leuven, Herestraat 49, 3000, Leuven, Belgium

    Koen Vanlede & Elena Levtchenko

  2. Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands

    Leo A. J. Kluijtmans

  3. Laboratory of Physiology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands

    Leo Monnens

Authors
  1. Koen Vanlede
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  2. Leo A. J. Kluijtmans
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  3. Leo Monnens
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  4. Elena Levtchenko
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Correspondence to Koen Vanlede.

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Vanlede, K., Kluijtmans, L.A.J., Monnens, L. et al. Urinary excretion of polyols and sugars in children with chronic kidney disease. Pediatr Nephrol 30, 1537–1540 (2015). https://doi.org/10.1007/s00467-015-3135-1

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  • DOI: https://doi.org/10.1007/s00467-015-3135-1

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