Pediatric Nephrology

, Volume 30, Issue 7, pp 1139–1145 | Cite as

Efficacy of transcutaneous interferential electrical stimulation in treatment of children with primary nocturnal enuresis: a randomized clinical trial

  • Abdol-Mohammad KajbafzadehEmail author
  • Lida Sharifi-Rad
  • Sarah Mozafarpour
  • Seyedeh-Sanam Ladi-Seyedian
Original Article



Electrical stimulation has been used as an alternative therapy for adult urinary syndromes and for children with constipation. We have evaluated the safety and efficacy of interferential (IF) electrical stimulation in children with nocturnal enuresis (NE).


This was a randomized clinical trial in which 54 children (23 girls, 31 boys) aged 6–14 years with primary NE were recruited and randomly divided into two groups. Children in the control group underwent standard urotherapy only (hydration, scheduled voiding, toilet training, diet), whereas children in the IF group (cases) were treated with standard urotherapy + 15 sessions of IF electrical stimulation for 20 min twice per week. An improvement score was calculated to identify relative decrease in wet nights after the treatment for each child. All children were followed for 1 year.


Overall, 15/27 (55.5 %) and 6/27 (22 %) of children in the IF and control groups responded to treatment at the 1-year follow-up (P = 0.01). The mean number of wet nights per week in the control and IF groups decreased from 5.4 ± 2 and 5.7 ± 2 to 3.3 ± 3 and 1.1 ± 2, respectively, at first evaluation (P = 0.003). The mean improvement score in the IF group was significantly higher than that of the control group after 1 year (78 vs. 46 %, respectively; P = 0.004).


Interferential therapy can be applied as a safe, effective and well-tolerable alternative therapy in the treatment of children with NE.


Nocturnal enuresis Interferential electrical stimulation Urinary incontinence Children Bladder 


Conflict of interest



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Copyright information

© IPNA 2015

Authors and Affiliations

  • Abdol-Mohammad Kajbafzadeh
    • 1
    Email author
  • Lida Sharifi-Rad
    • 2
  • Sarah Mozafarpour
    • 1
  • Seyedeh-Sanam Ladi-Seyedian
    • 1
  1. 1.Department of Pediatric Urology, Pediatric Urology Research Center, Children’s Hospital Medical Center, Pediatric Center of ExcellenceTehran University of Medical SciencesTehranIran
  2. 2.Department of Physical Therapy, Children’s Hospital Medical Center, Pediatric Center of ExcellenceTehran University of Medical SciencesTehranIran

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