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Paediatrics, insulin resistance and the kidney

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Abstract

Systemic insulin resistance is becoming more prevalent in the young due to modern lifestyles predisposing to the metabolic syndrome and obesity. There is also evidence that there are critical insulin-resistant phases for the developing child, including puberty, and that renal disease per se causes systemic insulin resistance. This review considers the factors that render children insulin resistant, as well as the accumulating evidence that the kidney is an insulin-responsive organ and could be affected by insulin resistance.

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Acknowledgements

RJC is supported by the MRC (MR/K010492/1) and Kidney Research UK. MM is supported by the National Institute of Health Research as an Academic Clinical Fellow.

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Authors and Affiliations

  1. Institute of Child Health, University College London, London, United Kingdom

    Matko Marlais

  2. Department of Paediatric Nephrology, Bristol Children’s Hospital, Upper Maudlin Street, Bristol, BS2 8BJ, United Kingdom

    Richard J. Coward

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  1. Matko Marlais
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  2. Richard J. Coward
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Correspondence to Richard J. Coward.

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Marlais, M., Coward, R.J. Paediatrics, insulin resistance and the kidney. Pediatr Nephrol 30, 1217–1224 (2015). https://doi.org/10.1007/s00467-014-2890-8

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  • DOI: https://doi.org/10.1007/s00467-014-2890-8

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