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The nephrotic syndrome: pathogenesis and treatment of edema formation and secondary complications

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Pediatric Nephrology Aims and scope Submit manuscript

Abstract

Nephrotic syndrome is an important clinical condition affecting both children and adults. Studies suggest that the pathogenesis of edema in individual patients may occur via widely variable mechanisms, i.e., intravascular volume underfilling versus overfilling. Managing edema should therefore be directed to the underlying pathophysiology. Nephrotic syndrome is also associated with clinically important complications related to urinary loss of proteins other than albumin. This educational review focuses on the pathophysiology and management of edema and secondary complications in patients with nephrotic syndrome.

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Authors and Affiliations

  1. Children’s Hospital Colorado/University of Colorado, Anschutz Medical Campus, 13123 East 16th Avenue, Box B328, Aurora, CO, 80045, USA

    Melissa A. Cadnapaphornchai

  2. University of Colorado School of Medicine, Aurora, CO, USA

    Oleksandra Tkachenko, Dmitry Shchekochikhin & Robert W. Schrier

  3. Division of Renal Diseases & Hypertension, University of Colorado, 12700 East 19th Avenue, C281, Aurora, CO, 80045, USA

    Robert W. Schrier

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  1. Melissa A. Cadnapaphornchai
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  2. Oleksandra Tkachenko
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  3. Dmitry Shchekochikhin
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  4. Robert W. Schrier
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Correspondence to Melissa A. Cadnapaphornchai.

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1. C

2. C

3. D

4. B

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Cadnapaphornchai, M.A., Tkachenko, O., Shchekochikhin, D. et al. The nephrotic syndrome: pathogenesis and treatment of edema formation and secondary complications. Pediatr Nephrol 29, 1159–1167 (2014). https://doi.org/10.1007/s00467-013-2567-8

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