Pediatric Nephrology

, Volume 29, Issue 6, pp 979–988

Rational use of antihypertensive medications in children

Educational Review

DOI: 10.1007/s00467-013-2510-z

Cite this article as:
Ferguson, M.A. & Flynn, J.T. Pediatr Nephrol (2014) 29: 979. doi:10.1007/s00467-013-2510-z


Hypertension has traditionally been regarded as an uncommon diagnosis in childhood and adolescence; however, there is compelling evidence to suggest that its prevalence is on the rise, particularly in those with obesity. As a result, pediatricians increasingly are asked to evaluate and manage patients with elevated blood pressure. An increased emphasis on conducting drug trials in children over the last 15 years has yielded important advances with respect to evidence-based data regarding the efficacy and safety of antihypertensive medications in children and adolescents. Unfortunately, data to definitively guide selection of initial agents is lacking. This article will present guidelines for the appropriate use of antihypertensive medications in the pediatric population, including the rational approach to selecting an appropriate medication with respect to pathophysiology, putative benefit, and likelihood for side effects.


Hypertension Primary hypertension Renal artery stenosis Renin Obesity Chronic kidney disease Athlete 

Copyright information

© IPNA 2013

Authors and Affiliations

  1. 1.Division of Nephrology, Boston Children’s Hospital, Department of Pediatrics Harvard Medical SchoolBoston Children’s HospitalBostonUSA
  2. 2.Division of Nephrology, Seattle Children’s Hospital, Department of PediatricsUniversity of Washington School of MedicineSeattleUSA

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