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Renal impairment in children with posterior urethral valves

Pediatric Nephrology volume 28, pages 927–931 (2013)Cite this article

An Erratum to this article was published on 29 March 2014

Abstract

Background

Posterior urethral valves (PUV) are a common cause of end-stage renal failure in childhood. Our aim was to describe a cohort of patients with PUV and to investigate the predictors of renal impairment.

Methods

We performed a retrospective chart review of children with PUV who were followed at King Abdulaziz University hospital between 2002 and 2011.

Results

The cohort comprised 68 boys. There was a significant difference in the duration of follow-up (p = 0.024), nadir serum creatinine (p < 0.001), and last known serum creatinine level (p = 0.001) between the patients with and without renal impairment. The duration of follow-up appeared to be a significant predictor for serum creatinine doubling (p = 0.003; odds ratio, 1.8). There was no difference in the age of presentation, age at the time of the study, and first or last serum creatinine between children who initially had vesicostomy and children who had ablation.

Conclusions

Ablation of PUV or vesicostomy did not influence kidney function in our study cohort. Children with a normal nadir serum creatinine who presented early had a better outcome.

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Acknowledgments

This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah under grand number (432/003-d). The authors therefore acknowledge with thanks the technical and financial support of DSR.

The authors would also like to thank members of the Clinical Research Unit at KAUH (Princila Mukoko, MD, Ali Kabouche, PhD, and Kalvin Balucanag) for their assistance.

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Affiliations

  1. Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, PO Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia

    Jameela Abdulaziz Kari, Sherif El-Desoky, Othman Radawi, Hosam Ghabra, Faten Basnawi & Ohood Bahrawi

  2. Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Youssef Farag & Ajay Singh

  3. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Youssef Farag & Ajay Singh

  4. Department of Urology, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

    Hisham Mosli, Abdul-Malik Altyieb, Ahmad Al Sayad & Hassan Farsi

Authors
  1. Jameela Abdulaziz Kari
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  2. Sherif El-Desoky
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  3. Youssef Farag
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  4. Hisham Mosli
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  5. Abdul-Malik Altyieb
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  6. Ahmad Al Sayad
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  7. Othman Radawi
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  8. Hosam Ghabra
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  9. Faten Basnawi
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  10. Ohood Bahrawi
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  11. Ajay Singh
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  12. Hassan Farsi
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Corresponding author

Correspondence to Jameela Abdulaziz Kari.

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Cite this article

Kari, J.A., El-Desoky, S., Farag, Y. et al. Renal impairment in children with posterior urethral valves. Pediatr Nephrol 28, 927–931 (2013). https://doi.org/10.1007/s00467-012-2390-7

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  • DOI: https://doi.org/10.1007/s00467-012-2390-7

Keywords

  • Renal impairment
  • Posterior urethral valves
  • Chronic kidney disease
  • Vesicostomy
  • Valve ablation