Pediatric Nephrology

, Volume 28, Issue 3, pp 409–414

Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from KDIGO

  • Rebecca M. Lombel
  • Elisabeth M. Hodson
  • Debbie S. Gipson
Educational Review

DOI: 10.1007/s00467-012-2304-8

Cite this article as:
Lombel, R.M., Hodson, E.M. & Gipson, D.S. Pediatr Nephrol (2013) 28: 409. doi:10.1007/s00467-012-2304-8


Kidney Disease: Improving Global Outcomes (KDIGO) recently published the clinical practice guideline on glomerulonephritis (GN) to assist the practitioner caring for patients with GN. Chapter 4 of the guideline focuses on managing children aged 1–18 years with steroid-resistant nephrotic syndrome (SRNS), defined by an inability to achieve complete remission with corticosteroid therapy. Guideline development followed a thorough evidence review, and management recommendations and suggestions were based on the best available evidence. Limitations of the evidence, including the paucity of large-scale randomized controlled trials, are discussed. This article provides both the guideline recommendations and a brief review of relevant treatment trials related to each recommendation. This précis serves as a summary of the complete guidelines recently published.


Clinical practice guidelines Steroid-resistant nephrotic syndrome Children Management 

Copyright information

© IPNA 2012

Authors and Affiliations

  • Rebecca M. Lombel
    • 1
    • 5
  • Elisabeth M. Hodson
    • 2
    • 3
  • Debbie S. Gipson
    • 1
    • 4
  1. 1.Division of Nephrology, Department of Pediatrics and Communicable DiseasesUniversity of MichiganAnn ArborUSA
  2. 2.Centre for Kidney ResearchThe Children’s Hospital at WestmeadWestmead, SydneyAustralia
  3. 3.Sydney School of Public HealthUniversity of SydneySydneyAustralia
  4. 4.Michigan Institute for Clinical and Health ResearchUniversity of MichiganAnn ArborUSA
  5. 5.Pediatric NephrologyC.S. Mott Children’s HospitalAnn ArborUSA

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