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Hypertension in infancy: diagnosis, management and outcome

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An Erratum to this article was published on 10 August 2011

Abstract

Advances in the ability to identify, evaluate, and care for infants with hypertension, coupled with advances in the practice of Neonatology, have led to an increased awareness of hypertension in modern neonatal intensive care units. This review will present updated data on blood pressure values in neonates, with a focus on the changes that occur over the first days and weeks of life in both term and preterm infants. Optimal blood pressure measurement techniques as well as the differential diagnosis of hypertension in the neonate and older infants will be discussed. Recommendations for the optimal immediate and long-term evaluation and treatment, including potential treatment parameters, will be presented. We will also review additional information on outcome that has become available over the past decade.

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References

  1. Adelman RD (1978) Neonatal hypertension. Pediatr Clin N Am 25:99–110

    CAS  Google Scholar 

  2. Watkinson M (2002) Hypertension in the newborn baby. Arch Dis Child Fetal Neonatal Ed 86:F78–F88

    Article  PubMed  CAS  Google Scholar 

  3. Flynn JT (2000) Neonatal hypertension: diagnosis and management. Pediatr Nephrol 14:332–341

    Article  PubMed  CAS  Google Scholar 

  4. Buchi KF, Siegler RL (1986) Hypertension in the first month of life. J Hypertens 4:525–528

    Article  PubMed  CAS  Google Scholar 

  5. Skalina MEL, Kliegman RM, Fanaroff AA (1986) Epidemiology and management of severe symptomatic neonatal hypertension. Am J Perinatol 3:235–239

    Article  PubMed  CAS  Google Scholar 

  6. Singh HP, Hurley RM, Myers TF (1992) Neonatal hypertension: incidence and risk factors. Am J Hypertens 5:51–55

    PubMed  CAS  Google Scholar 

  7. American Academy of Pediatrics Committee on Fetus and Newborn (1993) Routine evaluation of blood pressure, hematocrit and glucose in newborns. Pediatrics 92:474–476

    Google Scholar 

  8. Seliem WA, Falk MC, Shadbolt B, Kent AL (2007) Antenatal and postnatal risk factors for neonatal hypertension and infant follow-up. Pediatr Nephrol 22:2081–2087

    Article  PubMed  Google Scholar 

  9. Friedman AL, Hustead VA (1987) Hypertension in babies following discharge from a neonatal intensive care unit. Pediatr Nephrol 1:30–34

    Article  PubMed  CAS  Google Scholar 

  10. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114[2 Suppl 4th Report]:555–76

  11. Park M, Guntheroth W (1970) Direct blood pressure measurements in brachial and femoral arteries in children. Circulation 41:231–237

    PubMed  CAS  Google Scholar 

  12. Butt W, Whyte H (1984) Blood pressure monitoring in neonates: Comparison of umbilical and peripheral artery catheter measurements. J Pediatr 105:630–632

    Article  PubMed  CAS  Google Scholar 

  13. Low JA, Panagiotopoulos C, Smith JT, Tang W, Derrick EJ (1995) Validity of newborn oscillometric blood pressure. Clin Invest Med 18:163–167

    PubMed  CAS  Google Scholar 

  14. Kimble K, Darnall R, Yelderman M, Ariagno R, Ream A (1981) An automated oscillometric technique for estimating mean arterial pressure in critically ill newborns. Anesthesiology 54:423–425

    Article  PubMed  CAS  Google Scholar 

  15. Park M, Menard S (1987) Accuracy of blood pressure measurement by the Dinamap monitor in infants and children. Pediatrics 79:907–914

    PubMed  CAS  Google Scholar 

  16. Park MK, Menard SM (1989) Normative oscillometric blood pressure values in the first 5 years of life in an office setting. Am J Dis Child 143:860–864

    PubMed  CAS  Google Scholar 

  17. Dannevig I, Dale H, Liestol K, Lindemann R (2005) Blood pressure in the neonate: Three non-invasive oscillometric pressure monitors compared with invasively measure blood pressure. Acta Pediatr 94:191–196

    Article  Google Scholar 

  18. O’Shea J, Dempsey E (2009) A comparison of blood pressure measurements in newborns. Am J Perinatol 26:113–116

    Article  PubMed  Google Scholar 

  19. Gupta H, Scopes J (1965) Observations on blood pressure in newborn infants. Arch Dis Child 40:637–644

    Article  PubMed  CAS  Google Scholar 

  20. Duncan A, Rosenfeld C, Morgan J, Ahmad N, Heyne R (2008) Interrater reliability and effect of state on blood pressure measurements in infants 1 to 3 years of age. Pediatrics 122:e590–e594

    Article  PubMed  Google Scholar 

  21. Sonesson S, Broberger U (1987) Arterial blood pressure in the very low birth weight neonate: Evaluation of an automatic oscillometric technique. Acta Paediatr Scand 76:338–341

    Article  PubMed  CAS  Google Scholar 

  22. Nwankwo M, Lorenz J, Gardiner J (1997) A standard protocol for blood pressure measurement in the newborn. Pediatrics 99:E10

    Article  PubMed  CAS  Google Scholar 

  23. de Swiet M, Fayers P, Shinebourne EA (1980) Systolic blood pressure in a population of infants in the first year of life: the Brompton study. Pediatrics 65:1028–1035

    PubMed  Google Scholar 

  24. Pejovic B, Peco-Antic A, Marinkovic-Eric J (2007) Blood pressure in non-critically ill preterm and full-term neonates. Pediatr Nephrol 22:249–257

    Article  PubMed  Google Scholar 

  25. Kent A, Kecskes Z, Shadbolt B, Falk M (2007) Normative blood pressure data in the early neonatal period. Pediatr Nephrol 22:1335–1341

    Article  PubMed  Google Scholar 

  26. Kent A, Meskell S, Falk M, Shadbolt B (2009) Normative blood pressure data in non-ventilated premature neonates from 28-36 weeks gestation. Pediatr Nephrol 24:141–146

    Article  PubMed  Google Scholar 

  27. Lurbe E, Garcia-Vicent C, Torro I, Fayos J, Aguilar F, de Llano J, Fuertes G, Redon J (2007) First-year blood pressure increase steepest in low birthweight newborns. J Hypertens 25:81–86

    Article  PubMed  CAS  Google Scholar 

  28. Kent A, Kecskes Z, Shadbolt B, Falk M (2007) Blood pressure in the first year of life in healthy infants born at term. Pediatr Nephrol 22:1743–1749

    Article  PubMed  Google Scholar 

  29. Zubrow AB, Hulman S, Kushner H, Falkner B (1995) Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. J Perinatol 15:470–479

    PubMed  CAS  Google Scholar 

  30. Hegyi T, Anwar M, Carbone MT, Ostfeld B, Hiatt M, Koons A, Pinto-Martin J, Paneth N (1996) Blood pressure ranges in premature infants: II. The first week of life. Pediatr 97:336–342

    CAS  Google Scholar 

  31. Georgieff MK, Mills MM, Gomez-Marin O, Sinaiko AR (1996) Rate of change of blood pressure in premature and full term infants from birth to 4 months. Pediatr Nephrol 10:152–155

    PubMed  CAS  Google Scholar 

  32. Task Force on Blood Pressure Control in Children (1987) Report of the Second Task Force on Blood Pressure Control in Children—1987. National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda

  33. Neal WA, Reynolds JW, Jarvis CW, Williams HJ (1972) Umbilical artery catheterization: demonstration of arterial thrombosis by aortography. Pediatrics 50:6–13

    PubMed  CAS  Google Scholar 

  34. Seibert JJ, Taylor BJ, Williamson SL, Williams BJ, Szabo JS, Corbitt SL (1987) Sonographic detection of neonatal umbilical-artery thrombosis: clinical correlation. Am J Roentgenol 148:965–968

    CAS  Google Scholar 

  35. Ford KT, Teplick SK, Clark RE (1974) Renal artery embolism causing neonatal hypertension. Radiology 113:169–170

    PubMed  CAS  Google Scholar 

  36. Bauer SB, Feldman SM, Gellis SS, Retik AB (1975) Neonatal hypertension: a complication of umbilical-artery catheterization. N Engl J Med 293:1032–1033

    Article  PubMed  CAS  Google Scholar 

  37. Plumer LB, Kaplan GW, Mendoza SA (1976) Hypertension in infants—a complication of umbilical arterial catheterization. J Pediatr 89:802–805

    Article  PubMed  CAS  Google Scholar 

  38. Merten DF, Vogel JM, Adelman RD, Goetzman BW, Bogren HG (1978) Renovascular hypertension as a complication of umbilical arterial catheterization. Radiology 126:751–757

    PubMed  CAS  Google Scholar 

  39. Brooks WG, Weibley RE (1987) Emergency department presentation of severe hypertension secondary to complications of umbilical artery catheterization. Pediatr Emerg Care 3:104–106

    Article  PubMed  Google Scholar 

  40. Goetzman BW, Stadalnik RC, Bogren HG, Balnkenship WJ, Ikeda RM, Thayer J (1975) Thrombotic complications of umbilical artery catheters: a clinical and radiographic study. Pediatrics 56:374–379

    PubMed  CAS  Google Scholar 

  41. Wesström G, Finnström O, Stenport G (1979) Umbilical artery catheterization in newborns I. Thrombosis in relation to catheter type and position. Acta Paediatr Scand 68:575–581

    Article  PubMed  Google Scholar 

  42. Boo NY, Wong NC, Zulkifli SS, Lye MS (1999) Risk factors associated with umbilical vascular catheter-associated thrombosis in newborn infants. J Paediatr Child Health 35:460–465

    Article  PubMed  CAS  Google Scholar 

  43. Barrington KJ (2010) Umbilical artery catheters in the newborn: effects of catheter materials. Cochrane Database of Syst Rev: CD000505. doi:10.1002/14651858.CD000505

  44. Evans DJ, Silverman M, Bowley NB (1981) Congenital hypertension due to unilateral renal vein thrombosis. Arch Dis Child 56:306–308

    Article  PubMed  CAS  Google Scholar 

  45. Mocan H, Beattie TJ, Murphy AV (1991) Renal venous thrombosis in infancy: long-term follow-up. Pediatr Nephrol 5:45–49

    Article  PubMed  CAS  Google Scholar 

  46. Zigman A, Yazbeck S, Emil S, Nguyen L (2000) Renal vein thrombosis: a 10-year review. J Pediatr Surg 35:1540–1542

    Article  PubMed  CAS  Google Scholar 

  47. Winyard PJ, Bharucha T, De Bruyn R, Dillon MJ, van't Hoff W, Trompeter RS, Liesner R, Wade A, Rees L (2006) Perinatal renal venous thrombosis: presenting renal length predicts outcome. Arch Dis Child Fetal Neonatal Ed 91:F273–F278

    Article  PubMed  CAS  Google Scholar 

  48. Marks SD, Massicotte MP, Steele BT, Matsell DG, Filler G, Shah PS, Perlman M, Rosenblum ND, Shah VS (2005) Neonatal renal venous thrombosis: clinical outcomes and prevalence of prothrombotic disorders. J Pediatr 146:811–816

    Article  PubMed  Google Scholar 

  49. Kiessling SG, Wadhwa N, Kriss VM, Iocono J, Desai NS (2007) An unusual case of severe therapy-resistant hypertension in a newborn. Pediatrics 119:e301–e304

    Article  PubMed  Google Scholar 

  50. Tullus K, Brennan E, Hamilton G, Lord R, McLaren CA, Marks SD, Roebuck DJ (2008) Renovascular hypertension in children. Lancet 371:1453–1663

    Article  PubMed  CAS  Google Scholar 

  51. Das BB, Recto M, Shoemaker L, Mitchell M, Austin EH (2008) Midaortic syndrome presenting as neonatal hypertension. Pediatr Cardiol 29:1000–1001

    Article  PubMed  Google Scholar 

  52. Sethna CB, Kaplan BS, Cahill AM, Velazquez OC, Meyers KE (2008) Idiopathic mid-aortic syndrome in children. Pediatr Nephrol 23:1135–1142

    Article  PubMed  Google Scholar 

  53. Milner LS, Heitner R, Thomson PD, Levin SE, Rothberg AD, Beale P, Ninin DT (1984) Hypertension as the major problem of idiopathic arterial calcification of infancy. J Pediatr 105:934–938

    Article  PubMed  CAS  Google Scholar 

  54. Ciana G, Colonna F, Forleo V, Brizzi F, Benettoni A, de Vonderweid U (1997) Idiopathic arterial calcification of infancy: effectiveness of prostaglandin infusion for treatment of secondary hypertension refractory to conventional therapy: case report. Pediatr Cardiol 18:67–71

    Article  PubMed  CAS  Google Scholar 

  55. Dorman DC, Reye RDK, Reid RR (1966) Renal-artery stenosis in the rubella syndrome. Lancet 1:790–792

    PubMed  Google Scholar 

  56. Fick GM, Johnson AM, Strain JD, Kimberling WJ, Kumar S, Manco-Johnson ML, Duley IT, Gabow PA (1993) Characteristics of very early onset autosomal dominant polycystic kidney disease. J Am Soc Nephrol 3:1863–1870

    PubMed  CAS  Google Scholar 

  57. MacDermot KD, Saggar-Malik AK, Economides DL, Jeffery S (1998) Prenatal diagnosis of autosomal dominant polycystic kidney disease (PKD1) presenting in utero and prognosis for very early onset disease. J Med Genet 35:13–16

    Article  PubMed  CAS  Google Scholar 

  58. Guay-Woodford LM, Desmond RA (2003) Autosomal recessive polycystic kidney disease: the clinical experience in North America. Pediatrics 111:1072–1080

    Article  PubMed  Google Scholar 

  59. Susskind MR, Kim KS, King LR (1989) Hypertension and multicystic kidney. Urology 34:362–366

    Article  PubMed  CAS  Google Scholar 

  60. Angermeier KW, Kay R, Levin H (1992) Hypertension as a complication of multicystic dysplastic kidney. Urology 39:55–58

    Article  PubMed  CAS  Google Scholar 

  61. Webb NJA, Lewis MA, Bruce J, Gough DCS, Ladusans EJ, Thomson APJ, Postlethwaite RJ (1997) Unilateral multicystic dysplastic kidney: the case for nephrectomy. Arch Dis Child 76:31–34

    Article  PubMed  CAS  Google Scholar 

  62. Lanzarini VV, Furusawa EA, Sadeck L, Leone CR, Vaz FAC, Koch VH (2006) Neonatal arterial hypertension in nephrourological malformations in a tertiary care hospital. J Hum Hypertens 20:679–683

    Article  PubMed  CAS  Google Scholar 

  63. Gilboa N, Urizar RE (1983) Severe hypertension in newborn after pyeloplasty of hydronephrotic kidney. Urology 22:179–182

    Article  PubMed  CAS  Google Scholar 

  64. Riehle RA Jr, Vaughan ED Jr (1981) Renin participation in hypertension associated with unilateral hydronephrosis. J Urol 126:243–246

    PubMed  Google Scholar 

  65. Cadnapaphornchai P, Aisenbrey G, McDonald KM, Burke TJ, Schrier RW (1978) Prostaglandin-mediated hyperemia and renin-mediated hypertension during acute ureteral obstruction. Prostaglandins 16:965–971

    Article  PubMed  CAS  Google Scholar 

  66. Tokunaka S, Osanai H, Hashimoto H, Takamura T, Yachiku S, Mori Y (1987) Severe hypertension in infant with unilateral hypoplastic kidney. Urology 29:618–620

    Article  PubMed  CAS  Google Scholar 

  67. Wilson BJ, Flynn JT (1998) Familial, atypical hemolytic uremic syndrome in a premature infant. Pediatr Nephrol 12:782–784

    Article  PubMed  CAS  Google Scholar 

  68. Abman SH, Warady BA, Lum GM, Koops BL (1984) Systemic hypertension in infants with bronchopulmonary dysplasia. J Pediatr 104:929–931

    Google Scholar 

  69. Abman SH (2002) Monitoring cardiovascular function in infants with chronic lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed 87:F15–F18

    Article  PubMed  CAS  Google Scholar 

  70. Alagappan A, Malloy MH (1998) Systemic hypertension in very low-birth weight infants with bronchopulmonary dysplasia: incidence and risk factors. Am J Perinatol 15:3–8

    Article  PubMed  CAS  Google Scholar 

  71. Anderson AH, Warady BA, Daily DK, Johnson JA, Thomas MK (1993) Systemic hypertension in infants with severe bronchopulmonary dysplasia: associated clinical factors. Am J Perinatol 10:190–119

    PubMed  CAS  Google Scholar 

  72. Schell-Feith EA, Kist-van Holthe JE, van der Heijden AJ (2010) Nephrocalcinosis in preterm neonates. Pediatr Nephrol 25:221–230

    Article  PubMed  Google Scholar 

  73. Abman SH (2002) Moniotring cardiovascular function in infants with chronic lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed 87:F15–F18

    Article  PubMed  CAS  Google Scholar 

  74. Manalich R, Reyes L, Herrera M, Melendi C, Fundora I (2000) Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int 58:770–773

    Article  PubMed  CAS  Google Scholar 

  75. Rodríguez MM, Gómez AH, Abitbol CL, Chandar JJ, Duara S, Zilleruelo GE (2004) Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol 7:17–25

    Article  PubMed  Google Scholar 

  76. Abitbol CL, Bauer CR, Montane B, Chandar J, Duara S, Zilleruelo G (2003) Long-term follow-up of extremely low birth weight infants with neonatal renal failure. Pediatr Nephrol 18:887–893

    Article  PubMed  Google Scholar 

  77. Baum M (2010) Role of the kidney in the prenatal and early postnatal programming of hypertension. Am J Physiol Ren Physiol 298:F235–F247

    Article  CAS  Google Scholar 

  78. Abitbol CL, Ingelfinger J (2009) Nephron mass and cardiovascular and renal disease risks. Semin Nephrol 29:445–454

    Article  PubMed  Google Scholar 

  79. Rodríguez-Soriano J, Aguirre M, Oliveros R, Vallo A (2005) Long-term renal follow-up of extremely low birth weight infants. Pediatr Nephrol 20:579–584

    Article  PubMed  Google Scholar 

  80. O'Sullivan JJ, Derrick G, Darnell R (2002) Prevalence of hypertension in children after early repair of coarctation of the aorta: a cohort study using casual and 24 hour blood pressure measurement. Heart 88:163–166

    Article  PubMed  Google Scholar 

  81. Seirafi PA, Warner KG, Geggel RL, Payne DD, Cleveland RJ (1998) Repair of coarctation of the aorta during infancy minimizes the risk of late hypertension. Ann Thorac Surg 66:1378–1382

    Article  PubMed  CAS  Google Scholar 

  82. Mimouni M, Kaufman H, Roitman A, Moraq C, Sadan N (1985) Hypertension in a neonate with 11 beta-hydroxylase deficiency. Eur J Pediatr 143:231–233

    Article  PubMed  CAS  Google Scholar 

  83. Speiser PW, White PC (2003) Congenital adrenal hyperplasia. New Engl J Med 349:776–788

    Article  PubMed  CAS  Google Scholar 

  84. Torre JJ, Bloomgarden ZT, Dickey RA, Hogan MJ, Janick JJ, Jyothinagaram SG, Siragy HM (2006) American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of hypertension. Endocr Pract 12:193–222

    PubMed  Google Scholar 

  85. Vehaskari VM (2009) Heritable forms of hypertension. Pediatr Nephrol 24:1929–1937

    Article  PubMed  Google Scholar 

  86. Pozzan GB, Armanini D, Cecchetto G, Opocher G, Rigon F, Fassina A, Zacchello F (1997) Hypertensive cardiomegaly caused by an aldosterone-secreting adenoma in a newborn. J Endocrinol Investig 20:86–89

    CAS  Google Scholar 

  87. Malagon-Rogers M (2004) Non-glucocorticoid-remediable aldosteronism in an infant with low-renin hypertension. Pediatr Nephrol 19:235–236

    Article  PubMed  Google Scholar 

  88. Schonwetter BS, Libber SM, Jones D Jr, Park KJ, Plotnick LP (1983) Hypertension in neonatal hyperthyroidism. Am J Dis Child 137:954–955

    PubMed  CAS  Google Scholar 

  89. Ortiz LA, Quan A, Weinberg A, Baum M (2001) Effect of prenatal dexamethasone on rat renal development. Kidney Int 59:1663–1669

    Article  PubMed  CAS  Google Scholar 

  90. Seckl JR (2004) Prenatal glucocorticoids and long-term programming. Eur J Endocrinol 151[Supp 3]:U49–U62

    Article  PubMed  CAS  Google Scholar 

  91. Dalziel SR, Walker NK, Parag V, Mantell C, Rea HH, Rodgers A, Harding JE (2005) Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet 365:1856–1862

    Article  PubMed  CAS  Google Scholar 

  92. Greenough A, Emery EF, Gamsu HR (1992) Dexamethasone and hypertension in preterm infants. Eur J Pediatr 151:134–135

    Article  PubMed  CAS  Google Scholar 

  93. Smets K, Vanhaesebrouck P (1996) Dexamethasone associated systemic hypertension in low birth weight babies with chronic lung disease. Eur J Pediatr 155:573–575

    Article  PubMed  CAS  Google Scholar 

  94. Greher M, Hartmann T, Winkler M, Zimpfer M, Crabnor CM (1998) Hypertension and pulmonary edema associated with subconjunctival phenylephrine in a 2-month old child during cataract extraction. Anesthesiology 88:1394–1396

    Article  PubMed  CAS  Google Scholar 

  95. Dube SK, Jhaveri RC, Rosenfeld W, Evans HE, Khan F, Spergel G (1981) Urinary catecholamines, plasma renin activity and blood pressure in newborns: effects of narcotic withdrawal. Dev Pharmacol Ther 3:83–87

    PubMed  CAS  Google Scholar 

  96. Horn PT (1992) Persistent hypertension after prenatal cocaine exposure. J Pediatr 121:288–291

    Article  PubMed  CAS  Google Scholar 

  97. Koo WWK, Tsang RC (2005) Calcium and magnesium homeostasis. In: MacDonald MG, Seshia MMK, Mullett MD (eds) Avery’s neonatology: pathophysiology and management of the newborn, 6th edn. Lippincott-Williams and Wilkins, Philadelphia, pp 847–875

    Google Scholar 

  98. Weinblatt ME, Heisel MA, Siegel SE (1983) Hypertension in children with neurogenic tumors. Pediatrics 71:947–951

    PubMed  CAS  Google Scholar 

  99. Malone PS, Duffy PG, Ransley PG, Risdon RA, Cook T, Taylor M (1989) Congenital mesoblastic nephroma, renin production, and hypertension. J Pediatr Surg 24:599–600

    Article  PubMed  CAS  Google Scholar 

  100. Steinmetz JC (1989) Neonatal hypertension and cardiomegaly associated with a congenital neuroblastoma. Pediatr Pathol 9:577–582

    Article  PubMed  CAS  Google Scholar 

  101. Haberkern CM, Coles PG, Morray JP, Kennard SC, Sawin RS (1992) Intraoperative hypertension during surgical excision of neuroblastoma: case report and review of 20 years’ experience. Anesth Analg 75:854–858

    Article  PubMed  CAS  Google Scholar 

  102. Eden OB, Sills JA, Brown JK (1977) Hypertension in acute neurological diseases of childhood. Dev Med Child Neurol 19:437–445

    Article  PubMed  CAS  Google Scholar 

  103. American Academy of Pediatrics, Committee on Fetus and Newborn and Section on Surgery, Section on Anesthesiology and Pain Medicine, Canadian Paediatric Society, and Fetus and Newborn Committee (2006) Prevention and management of pain in the neonate. Update Pediatr 118:2231–2241

    Google Scholar 

  104. Boedy RF, Goldberg AK, Howell CG Jr, Hulse E, Edwards EG, Kanto WP (1990) Incidence of hypertension in infants on extracorporeal membrane oxygenation. J Pediatr Surg 25:258–261

    Article  PubMed  CAS  Google Scholar 

  105. Sell LL, Cullen ML, Lerner GR, Whittlesey GC, Shanley CJ, Klein MD (1987) Hypertension during extracorporeal membrane oxygenation: cause, effect and management. Surgery 102:724–730

    PubMed  CAS  Google Scholar 

  106. Hawkins KC, Watson AR, Rutter N (1995) Neonatal hypertension and cardiac failure. Eur J Pediatr 154:148–149

    Article  PubMed  CAS  Google Scholar 

  107. Tannenbaum J, Hulman S, Falkner B (1990) Relationship between plasma renin concentration and atrial natriuretic peptide in the human newborn. Am J Perinatol 7:174–177

    Article  PubMed  CAS  Google Scholar 

  108. Krüger C, Rauh M, Dörr HG (1998) Immunoreactive renin concentration in healthy children from birth to adolescence. Clin Chim Acta 274:15–27

    Article  PubMed  Google Scholar 

  109. Richer C, Hornych H, Amiel-Tison C, Relier JP, Giudicelli JF (1977) Plasma renin activity and its postnatal development in preterm infants. Preliminary report. Biol Neonate 31:301–304

    Article  PubMed  CAS  Google Scholar 

  110. Rieg T, Steigele H, Schnermann J, Richter K, Osswald H, Vallon V (2005) Requirement of intact adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine. J Pharmacol Exp Ther 313:403–409

    Article  PubMed  CAS  Google Scholar 

  111. Roth CG, Spottswood SE, Chan JC, Roth KS (2003) Evaluation of the hypertensive infant: a rational approach to diagnosis. Radiol Clin North Am 41:931–944

    Article  PubMed  Google Scholar 

  112. Flynn JT, Tullus K (2009) Severe hypertension in children and adolescents: pathophysiology and treatment. Pediatr Nephrol 24:1101–1112

    Article  PubMed  Google Scholar 

  113. Adelman RD, Coppo R (2000) Dillon MJ (2000) The emergency management of severe hypertension. Pediatr Nephrol 14:422–427

    Article  PubMed  CAS  Google Scholar 

  114. Flynn JT, Mottes TA, Brophy PB, Kershaw DB, Smoyer WE, Bunchman TE (2001) Intravenous nicardipine for treatment of severe hypertension in children. J Pediatr 139:38–43

    Article  PubMed  CAS  Google Scholar 

  115. Gouyon JB, Geneste B, Semama DS, Francoise M, Germain JF (1997) Intravenous nicardipine in hypertensive preterm infants. Arch Dis Child 76:F126–F127

    Article  CAS  Google Scholar 

  116. Wiest DB, Garner SS, Uber WE, Sade RM (1998) Esmolol for the management of pediatric hypertension after cardiac operations. J Thorac Cardiovas Surg 115:890–897

    Article  CAS  Google Scholar 

  117. Thomas CA, Moffett BS, Wagner JL, Mott AR, Feig DI (2010) Safety and efficacy of intravenous labetalol for hypertensive crisis in infants and small children. Pediatr Crit Care Med. doi:10.1097/PCC.0b013e3181e328d8

    Google Scholar 

  118. Benitz WE, Malachowski N, Cohen RS, Stevenson DK, Ariagno RL, Sunshine P (1985) Use of sodium nitroprusside in neonates: efficacy and safety. J Pediatr 106:102–110

    Article  PubMed  CAS  Google Scholar 

  119. Wells TG, Bunchman TE, Kearns GL (1990) Treatment of neonatal hypertension with enalaprilat. J Pediatr 117:664–667

    Article  PubMed  CAS  Google Scholar 

  120. Mason T, Polak MJ, Pyles L, Mullett M, Swanke C (1992) Treatment of neonatal renovascular hypertension with intravenous enalapril. Am J Perinatol 9:254–257

    Article  PubMed  CAS  Google Scholar 

  121. Flynn JT, Warnick SJ (2002) Isradipine treatment of hypertension in children: a single-center experience. Pediatr Nephrol 17:748–753

    Article  PubMed  Google Scholar 

  122. Miyashita Y, Peterson D, Rees JM, Flynn JT (2010) Isradipine treatment of acute hypertension in hospitalized children and adolescents. J Clin Hypertens Greenwich 12:850–855

    Article  PubMed  CAS  Google Scholar 

  123. MacDonald JL, Johnson CE, Jacobson P (1994) Stability of isradipine in an extemporaneously compounded oral liquid. Am J Hosp Pharm 51:2409–2411

    PubMed  CAS  Google Scholar 

  124. Flynn JT (2003) Safety of short-acting nifedipine in children with severe hypertension. Expert Opin Drug Saf 2:133–139

    Article  PubMed  CAS  Google Scholar 

  125. Englehardt B, Elliott S, Hazinski TA (1986) Short- and long-term effects of furosemide on lung function in infants with bronchopulmonary dysplasia. J Pediatr 109:1034–1039

    Article  Google Scholar 

  126. O’Dea RF, Mirkin BL, Alward CT, Sinaiko AR (1988) Treatment of neonatal hypertension with captopril. J Pediatr 113:403–406

    Article  PubMed  Google Scholar 

  127. Tack ED, Perlman JM (1988) Renal failure in sick hypertensive premature infants receiving captopril therapy. J Pediatr 112:805–810

    Article  PubMed  CAS  Google Scholar 

  128. Guron G, Friberg P (2000) An intact renin-angiotensin system is a prerequisite for normal renal development. J Hypertens 18:123–137

    Article  PubMed  CAS  Google Scholar 

  129. Hendren WH, Kim SH, Herrin JT, Crawford JD (1982) Surgically correctable hypertension of renal origin in childhood. Am J Surg 143:432–442

    Article  PubMed  CAS  Google Scholar 

  130. Rajpoot DK, Duel B, Thayer K (1999) Shanberg A (1999) Medically resistant neonatal hypertension: revisiting the surgical causes. J Perinatol 19:582–583

    Article  PubMed  CAS  Google Scholar 

  131. Bendel-Stenzel M, Najarian JS, Sinaiko AR (1995) Renal artery stenosis: long-term medical management before surgery. Pediatr Nephrol 10:147–151

    Google Scholar 

  132. Stanley JC, Zelenock GB, Messina LM, Wakefield TW (1995) Pediatric renovascular hypertension: a thirty-year experience of operative treatment. J Vasc Surg 21:212–227

    Article  PubMed  CAS  Google Scholar 

  133. Adelman RD (1987) Long-term follow-up of neonatal renovascular hypertension. Pediatr Nephrol 1:35–41

    Article  PubMed  CAS  Google Scholar 

  134. Caplan MS, Cohn RA, Langman CB, Conway JA, Ahkolnik A, Brouillette RT (1989) Favorable outcome of neonatal aortic thrombosis and renovascular hypertension. J Pediatr 115:291–295

    Article  PubMed  CAS  Google Scholar 

  135. Roy S, Dillon MJ, Trompeter RS, Barratt TM (1997) Autosomal recessive polycystic kidney disease: long-term outcome of neonatal survivors. Pediatr Nephrol 11:302–306

    Article  PubMed  CAS  Google Scholar 

  136. Mackenzie HS, Lawler EV, Brenner BM (1996) Congenital olionephropathy the fetal flaw in essential hypertension? Kidney Int 55:S30–S34

    CAS  Google Scholar 

  137. Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hypertension. N Engl J Med 348:101–108

    Article  PubMed  Google Scholar 

  138. Shankaran S, Das A, Bauer CR, Bada H, Lester B, Wright LR, Higgins R, Poole K (2006) Fetal origin of childhood disease: intrauterine growth restriction in term infants and risk for hypertension at 6 years of age. Arch Pediatr Adolesc Med 160:977–981

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Nephrology, Department of Pediatrics, University of British Columbia, BC Children’s Hospital, Vancouver, BC, Canada

    Janis M. Dionne

  2. Division of Pediatric Nephrology, Department of Pediatrics, University of Miami Miller School of Medicine/ Holtz Children’s Hospital, Miami, FL, USA

    Carolyn L. Abitbol

  3. Division of Nephrology, Seattle Children’s Hospital, Department of Pediatrics, University of Washington School of Medicine, 4800 Sand Point Way NE, M/S A-7931, Seattle, WA, 98105, USA

    Joseph T. Flynn

Authors
  1. Janis M. Dionne
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  2. Carolyn L. Abitbol
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  3. Joseph T. Flynn
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Correspondence to Joseph T. Flynn.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00467-011-1978-7

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Dionne, J.M., Abitbol, C.L. & Flynn, J.T. Hypertension in infancy: diagnosis, management and outcome. Pediatr Nephrol 27, 17–32 (2012). https://doi.org/10.1007/s00467-010-1755-z

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  • DOI: https://doi.org/10.1007/s00467-010-1755-z

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