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Isoprostane levels in urine of preterm newborns treated with ibuprofen for patent ductus arteriosus closure

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Abstract

Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU). PDA is strictly related to oxidative stress (OS) in neonates. This study tests the hypothesis that OS occurs in neonates with PDA and that IBU treatment reduces OS. Forty-three preterm babies with gestational age (GA) <33 weeks were studied prospectively. Three urine samples were collected: at time 0 (before starting treatment), time 1 (after pharmacological PDA closure), and time 2 (7 days after the end of treatment) in all patients. OS was studied by measuring urinary isoprostane (IPs) levels. The results showed significant changes in urinary IP levels from time 0 to time 2 (Kruskal–Wallis, p = 0.047). Time trend showed a significant decrease in IPs from time 0 to time 1 after IBU therapy (p = 0.0067). This decrease was followed by an increase in IPs levels 7 days after treatment. IBU therapy for PDA closure reduced the risk of OS related to free-radical (FR) generation. This antioxidant effect of IBU may be beneficial in preterm babies with PDA who are at high risk for OS.

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Acknowledgment

We thank EURAIBI FONDAZIONE ONLUS for support of this work.

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Authors and Affiliations

  1. Department of Pediatrics, Obstetrics and Reproductive Medicine, Division of Neonatology, University of Siena, Siena, Italy

    Mariangela Longini, Serafina Perrone, Piero Vezzosi, Fabrizio Proietti, Barbara Marzocchi & Giuseppe Buonocore

  2. Neonatal Intensive Care Unit, Puericultura Institute and Neonatal Section, University and Azienda Mista of Cagliari, Cagliari, Italy

    Vassilios Fanos & Roberto Antonucci

  3. Department of Organic Chemistry, University of Pavia, Pavia, 27100, Italy

    Enrico Brunoldi

Authors
  1. Mariangela Longini
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  2. Serafina Perrone
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  3. Piero Vezzosi
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  4. Fabrizio Proietti
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  5. Barbara Marzocchi
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  6. Giuseppe Buonocore
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  7. Vassilios Fanos
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  8. Roberto Antonucci
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  9. Enrico Brunoldi
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Correspondence to Mariangela Longini.

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Longini, M., Perrone, S., Vezzosi, P. et al. Isoprostane levels in urine of preterm newborns treated with ibuprofen for patent ductus arteriosus closure. Pediatr Nephrol 26, 105–109 (2011). https://doi.org/10.1007/s00467-010-1651-6

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  • DOI: https://doi.org/10.1007/s00467-010-1651-6

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