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Gout in pediatric renal transplant recipients

Abstract

Clinical gout has rarely been described after pediatric renal transplantation (RTx), although asymptomatic hyperuricemia is common in these patients. We describe three male pediatric patients who presented with gouty arthritis 7–8.5 years following RTx. Since receiving allopurinol, all patients had been free of gouty symptoms. To prevent severe bone marrow depletion, the dosage of azathioprine, an immunosupressant drug, was reduced by 50% to prevent interaction with allopurinol. Because atypical presentation of gout can occur, a high index of suspicion is needed to allow appropriate diagnosis of this disease in patients with skeletal pain after RTx.

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Acknowledgments

We thank Dr. Philip Went for providing photos of Fig. 2 and Dr. Jan Janzen for helping with the interpretation of the histopathology.

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The authors declare that they have no conflicts of interest in writing the article.

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Correspondence to Philippe Goetschel.

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Trück, J., Laube, G.F., von Vigier, R.O. et al. Gout in pediatric renal transplant recipients. Pediatr Nephrol 25, 2535–2538 (2010). https://doi.org/10.1007/s00467-010-1599-6

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  • DOI: https://doi.org/10.1007/s00467-010-1599-6

Keywords

  • Kidney transplantation
  • Gout
  • Hyperuricemia
  • Children
  • Azathioprine
  • Allopurinol