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Inflammatory activation in children with primary hypertension

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An Erratum to this article was published on 29 September 2010

Abstract

Low-grade inflammation plays a role in the pathogenesis of primary hypertension (PH) and target organ damage (TOD). We evaluated the profile of inflammatory mediators (CRP, RANTES, MIP-1β, MIP-1α, MCP-1, IL-6, angiogenin, adiponectin) in 30 healthy children (12.7 ± 3.3 years) and 44 patients with untreated PH (13.7 ± 2.7 years; n.s). Patients had greater concentrations of CRP, MIP-1β, and RANTES than controls (all p < 0.05). Children with metabolic syndrome (MS) had greater CRP than children without MS (p = 0.007) and CRP correlated with number of MS criteria, body mass index (BMI), visceral fat, deep subcutaneous fat assessed by magnetic resonance imaging, carotid intima-media thickness (cIMT), left ventricular mass index, and markers of oxidative stress. RANTES correlated with cholesterol, LDL cholesterol, ApoB, and ApoB/ApoA1. Angiogenin correlated with BMI, waist circumference, visceral fat, uric acid, and patients with cIMT>2SD had greater concentration of angiogenin than those with normal cIMT (p = 0.03). Adiponectin was lower in patients with cIMT>2SD than in those with normal cIMT (p = 0.02). No model explaining variability of TOD has been built. Elevated RANTES and MIP-1β and normal IL-6 and TNF-α levels indicate a vascular inflammatory process. Lack of correlation between CRP and chemokines suggests that vascular inflammation in PH precedes the systemic inflammatory changes.

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Acknowledgment

The study was supported by grant of Ministry of Science and Higher Education NN40710855134.

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Authors and Affiliations

  1. Department of Research, The Children’s Memorial Health Institute, Warsaw, Poland

    Mieczyslaw Litwin

  2. Department of Nephrology and Arterial Hypertension, The Children’s Memorial Health Institute, Warsaw, Poland

    Mieczyslaw Litwin & Anna Niemirska

  3. Department of Microbiology and Immunology, The Children’s Memorial Health Institute, Warsaw, Poland

    Jacek Michałkiewicz

  4. Department of Immunology, Nicolaus Copernicus University Collegium Medicum, Bydgoszcz, Poland

    Jacek Michałkiewicz, Lidia Gockowska & Izabela Kubiszewska

  5. Department of Biochemistry and Experimental Medicine, The Children’s Memorial Health Institute, Warsaw, Poland

    Aldona Wierzbicka & Zbigniew T. Wawer

  6. Department of Radioimmunology, The Children’s Memorial Health Institute, Warsaw, Poland

    Roman Janas

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  1. Mieczyslaw Litwin
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  2. Jacek Michałkiewicz
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  3. Anna Niemirska
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  7. Zbigniew T. Wawer
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Correspondence to Mieczyslaw Litwin.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00467-010-1643-6

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Litwin, M., Michałkiewicz, J., Niemirska, A. et al. Inflammatory activation in children with primary hypertension. Pediatr Nephrol 25, 1711–1718 (2010). https://doi.org/10.1007/s00467-010-1548-4

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  • DOI: https://doi.org/10.1007/s00467-010-1548-4

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