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Vitamin D insufficiency: implications for the immune system


Chronic kidney disease (CKD) is characterized by a loss of kidney function and dysregulation of vitamin D metabolism. Well known are the defects in final activation of vitamin D to 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], resulting in renal osteodystrophy. However, in recent years, 1,25(OH)2D3 has been identified as having effects far beyond calcium and bone metabolism. In this review, specific attention is given to the effects of 1,25(OH)2D3 on the immune system and the implications of vitamin D deficiency, a feature of many patients with CKD, on immune function.

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This work was supported by grants of the Flemish Research Foundation [Fonds Voor Wetenschappelijk Onderzoek (FWO) Vlaanderen G.0552.06 and G.0649.08, a postdoctoral fellowship for Conny Gysemans and Hannelie Korf and a clinical fellowship for Chantal Mathieu], of the Belgium Program on Interuniversity Poles of Attraction initiated by the Belgian State (IAP P5/17 and P6/40), of the Katholieke Universiteit Leuven (GOA 2004/10 and GOA 2009/10), of the 6th Framework Program of the European Union with acronym SAVEBETA as well as of the 7th Framework Program of the European Union with acronym NAIMIT and of the JDRF Center for Prevention of Beta Cell Therapy in Diabetes [grant number 4-2005-1327].

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Correspondence to Chantal Mathieu.

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Baeke, F., Gysemans, C., Korf, H. et al. Vitamin D insufficiency: implications for the immune system. Pediatr Nephrol 25, 1597–1606 (2010).

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  • Vitamin D
  • Immune modulation
  • Chronic kidney disease