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Final height of adults with childhood-onset steroid-responsive idiopathic nephrotic syndrome

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Abstract

The aim of this study was to evaluate the final stature of adults with childhood-onset steroid-responsive idiopathic nephrotic syndrome (INS) and the influence of disease-related issues on the achievement of their target heights. We analyzed 60 (41 male) patients and/or their records, with a minimum age of 19 years or at a Tanner’s pubertal stage 4 for boys or status postmenarche for girls, and normal glomerular filtration rate. Mean age at first and last consultation was 5.3 ± 2.4 years and 20.5 ± 3.1 years, respectively. Mean follow-up period was 15.10 years. Mean cumulative dose of prednisone was 1254 ± 831.40 mg/kg. Mean initial and final height Z scores (HtZ) were, respectively, −0.60 ± 1.0 and −0.64 ± 0.92 (p = 0.72). The final HtZ showed a significant correlation only with the initial HtZ and the target HtZ (THZ). Six patients achieved a final HtZ below −2, which in male patients correlated strongly to the initial HtZ and THZ. A strong correlation was demonstrated between final HtZ, initial HtZ, and THZ. INS-related issues did not prevent the final stature to reach the predicted target height.

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Authors and Affiliations

  1. Pediatric Nephrology Unit, Instituto da Criança of the Hospital das Clinicas of the School of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil

    Teresinha Lermen Donatti & Vera Hermina Koch

  2. Rua das Mangabeiras 91/81, 01233-010, São Paulo, Brazil

    Vera Hermina Koch

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  1. Teresinha Lermen Donatti
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  2. Vera Hermina Koch
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Correspondence to Vera Hermina Koch.

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Donatti, T.L., Koch, V.H. Final height of adults with childhood-onset steroid-responsive idiopathic nephrotic syndrome. Pediatr Nephrol 24, 2401–2408 (2009). https://doi.org/10.1007/s00467-009-1301-z

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  • DOI: https://doi.org/10.1007/s00467-009-1301-z

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