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Nephrogenic diabetes insipidus: treat with caution

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Abstract

Current therapy for congenital nephrogenic diabetes insipidus consists of appropriate water intake coupled with decreased urine output obtained by means of a low-sodium diet and a combination of thiazide diuretics with renal prostaglandins inhibitors or amiloride. We report a case of congenital nephrogenic diabetes insipidus that was complicated by paradoxical water intoxication secondary to liberal water intake and the initiation of hydrochlorothiazide and indomethacin combination therapy. This report emphasizes the importance of evaluating the water balance and of a quick response with strict protocols following the initiation of indomethacin and thiazide diuretics in nephrogenic diabetes insipidus.

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Authors and Affiliations

  1. Pediatric Intensive Care Unit and Department of Pediatrics, Centre Hospitalier du Mans, 72037, Le Mans, France

    Thierry Boussemart & Jacqueline Nsota

  2. Department of Genetics, Centre Hospitalier du Mans, 72037, Le Mans, France

    Dominique Martin–Coignard

  3. Nephrology Division and Department of Pediatrics, Centre Hospitalier Universitaire d’Angers, 49933, Angers, France

    Gérard Champion

Authors
  1. Thierry Boussemart
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  2. Jacqueline Nsota
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  3. Dominique Martin–Coignard
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  4. Gérard Champion
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Correspondence to Thierry Boussemart.

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Boussemart, T., Nsota, J., Martin–Coignard, D. et al. Nephrogenic diabetes insipidus: treat with caution. Pediatr Nephrol 24, 1761–1763 (2009). https://doi.org/10.1007/s00467-009-1187-9

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  • DOI: https://doi.org/10.1007/s00467-009-1187-9

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