Abstract
Chronic renal failure is a common complication of methylmalonic acidaemia (MMA). It is usually managed with haemodialysis and renal transplantation. We report the use of continuous cycling peritoneal dialysis (CCPD) for 20 months in a paediatric patient with chronic renal failure due to MMA. This procedure resulted in the elimination of 950 μmol methylmalonate (MM) per day and a fall in the plasma MM concentration from 3.9 to 0.74 mmol/l. As a result of this treatment, the frequency at which this patient was hospitalised was markedly reduced prior to a successful renal transplantation.
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Acknowledgements
We are grateful to Prof B. Fowler and Dr S. Krywawych for measuring methylmalonyl-CoA mutase activity and plasma and peritoneal MM concentrations, respectively, in this patient.
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Etuwewe, B., Jones, C.A., Mathur, S. et al. Peritoneal dialysis for chronic renal failure in a patient with methylmalonic acidaemia. Pediatr Nephrol 24, 1085–1087 (2009). https://doi.org/10.1007/s00467-008-1068-7
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DOI: https://doi.org/10.1007/s00467-008-1068-7