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Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice

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Abstract

Dopamine is important in the pathogenesis of hypertension because of abnormalities in receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified into D1-like (D1, D5) and D2-like (D2, D3, D4) subtypes, all of which are expressed in the kidney. Mice deficient in specific dopamine receptors have been generated to provide holistic assessment on the varying physiological roles of each receptor subtype. This review examines recent studies on these mutant mouse models and evaluates the impact of individual dopamine receptor subtypes on blood pressure regulation.

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Acknowledgment

This work is supported in part by grants from the National Institutes of Health, HL23081, DK39308, HL074940, and HL68686.

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Authors and Affiliations

  1. Department of Pediatrics, Georgetown University Medical Center, Washington, DC, USA

    Xiaoyan Wang, Van Anthony M. Villar, Ines Armando & Pedro A. Jose

  2. Department of Medicine, Georgetown University Medical Center, Washington, DC, USA

    Gilbert M. Eisner

  3. Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA, USA

    Robin A. Felder

  4. Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC, USA

    Pedro A. Jose

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  1. Xiaoyan Wang
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Wang, X., Villar, V.A.M., Armando, I. et al. Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice. Pediatr Nephrol 23, 2131–2146 (2008). https://doi.org/10.1007/s00467-008-0901-3

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