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Renal cell carcinoma in a patient with cystinosis and inflammatory bowel disease: a case report

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Abstract

An 18-year-old male patient with a history of cystinosis and inflammatory bowel disease, who was being treated with cysteamine and 6-mercaptopurine, had an incidental finding of a mass in the right kidney on a renal ultrasound to evaluate worsening renal insufficiency. Excisional biopsy demonstrated papillary renal cell carcinoma, Type 2. Renal cell carcinoma is typically a disease of older adults, and it is not known to be associated with cystinosis. This is the first published report of renal cell carcinoma in a patient with cystinosis.

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References

  1. Gahl W, Thoene J, Schneider J (2002) Cystinosis. N Engl J Med 347:111–121

    Article  Google Scholar 

  2. Kleta R, Kaskel F, Dohil R, Goodyer P, Guay-Woodford L, Harms E, Ingelfinger J, Koch V, Langman C, Leonard M, Mannon R, Sarwal M, Schneider J, Skovby F, Sonies B, Thoene G, Trauner D, Gahl W (2005) First NIH/Office of Rare Diseases Conference on Cystinosis: past, present, and future. Pediatr Nephrol 20:452–454

    Article  Google Scholar 

  3. Fleitz J, Wootton-Gorges S, Wyatt-Ashmead J, McGavran L, Koyle M, West D, Kurzrock E, Martin K, Odom L (2003) Renal cell carcinoma in long-term survivors of advanced stage neuroblastoma in early childhood. Pediatr Radiol 33:540–545

    Article  Google Scholar 

  4. Mejean A, Oudard S, Thiounn N (2003) Prognostic factors of renal cell carcinoma. J Urol 169:821–827

    Article  Google Scholar 

  5. Cohen H, McGovern F (2005) Renal-Cell Carcinoma. N Engl J Med 353:2477–2490

    Article  CAS  Google Scholar 

  6. Tsui K, Shvarts O, Smith R, Figlin R, DeKernion J, Belldegrun A (2000) Renal cell carcinoma: prognostic significance of incidentally detected tumors. J Urol 163:426–430

    Article  CAS  Google Scholar 

  7. Beck S, Patel M, Snyder M, Kattan M, Motzer R, Reuter V, Russo P (2003) Effect of papillary and chromophobe cell type on disease free survival after nephrectomy for renal cell carcinoma. Ann Surg Oncol 11:71–77

    Article  Google Scholar 

  8. Treen W, Rusnack E, Ragsdale B, Seikaly M, DiPalma J (1988) Inflammatory bowel disease in a patient with nephropathic cystinosis. Pediatrics 81:584–587

    Google Scholar 

  9. Satsangi J, Marshall J, Roskell D, Jewell D (1996) Ulcerative colitis complicated by renal cell carcinoma: a series of three patients. Gut 38:148–150

    Article  CAS  Google Scholar 

  10. Fraser A, Orchard T, Robinson E, Jewell D (2002) Long-term risk of malignancy after treatment of inflammatory bowel disease with azathioprine. Aliment Pharmacol Ther 16:1225–1232

    Article  CAS  Google Scholar 

  11. Kwon J, Farrell R (2005) The risk of lymphoma in the treatment of inflammatory bowel disease with immunosuppressive agents. Crit Rev Oncol Hematol 56:169–178

    Article  Google Scholar 

  12. Masunaga Y, Ohno K, Ogawa R, Hashiguchi M, Echizen H, Ogata H (2007) Meta-analysis of risk of malignancy with immunosuppressive drugs in inflammatory bowel disease. Ann Pharmacother 41:21–28

    Article  CAS  Google Scholar 

  13. Jeitner TM, Renton FJ (1996) Inhibition of the proliferation of human neural neoplastic cell lines by cysteamine. Cancer Lett 103:85–90

    Article  CAS  Google Scholar 

  14. Watanabe M, Kobayashi H, Ohta T (1994) Rapid inactivation of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a potent mutagen in chlorinated drinking water, by sulfhydryl compounds. Mutat Res 312:131–138

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Pediatric Hematology/Oncology, Children’s Hospital of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI, 53226, USA

    Cheryl Cameron & Michael E. Kelly

  2. Pediatric Nephrology, Emory University, Children’s Healthcare of Atlanta, 1405 Clifton Road NC, Atlanta, GA, 30322, USA

    Larry Greenbaum

  3. Pediatric Surgery, Children’s Hospital of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI, 53226, USA

    Thomas Sato

  4. Pediatric Pathology, Children’s Hospital of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI, 53226, USA

    Beth Trost

  5. Pediatric Radiologist, Children’s Hospital of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI, 53226, USA

    Brian Lundeen

Authors
  1. Cheryl Cameron
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  2. Larry Greenbaum
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  3. Thomas Sato
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  4. Beth Trost
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  5. Brian Lundeen
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  6. Michael E. Kelly
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Correspondence to Michael E. Kelly.

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Cameron, C., Greenbaum, L., Sato, T. et al. Renal cell carcinoma in a patient with cystinosis and inflammatory bowel disease: a case report. Pediatr Nephrol 23, 1167–1170 (2008). https://doi.org/10.1007/s00467-008-0773-6

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  • DOI: https://doi.org/10.1007/s00467-008-0773-6

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