Skip to main content

A case of cerebral salt-wasting syndrome associated with aseptic meningitis in an 8-year-old boy

Abstract

Cerebral salt-wasting syndrome is a disorder in which excessive natriuresis and subsequent hyponatremic dehydration occur in patients with intracranial diseases. Cerebral salt-wasting syndrome often develops in patients with severe neurosurgical disorders, such as hydrocephalus, cerebral infarction, and tuberculous meningitis. Here, we report on the case of an 8-year-old boy with cerebral salt-wasting syndrome associated with aseptic meningitis. He showed mild developmental retardation and had a history of convulsion. Four days after his admission, cerebral salt-wasting syndrome abruptly started: natriuresis and hyponatremia gradually improved over 10 days. To the best of our knowledge, this is the first report on cerebral salt-wasting syndrome associated with clinically benign aseptic meningitis.

This is a preview of subscription content, access via your institution.

Fig. 1

References

  1. Moller K, Larsen FS, Bie P, Skinhoj P (2001) The syndrome of inappropriate secretion of antidiuretic hormone and fluid restriction in meningitis—how strong is the evidence? Scand J Infect Dis 33:13–26

    CAS  Article  Google Scholar 

  2. Bianchetti MG, Thyssen HR, Laux-End R, Schaad UB (1996) Evidence for fluid volume depletion in hyponatraemic patients with bacterial meningitis. Acta Paediatr 85:1163–1166

    CAS  Article  Google Scholar 

  3. Peters JP, Welt LG, Sims EA, Orloff J, Needham J (1950) A salt-wasting syndrome associated with cerebral disease. Trans Assoc Am Physicians 63:57–64

    CAS  PubMed  Google Scholar 

  4. Schwartz WB, Bennett W, Curelop S (1957) A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med 23:529–542

    CAS  Article  Google Scholar 

  5. Ti LK, Kang SC, Cheong KF (1998) Acute hyponatraemia secondary to cerebral salt wasting syndrome in a patient with tuberculous meningitis. Anaesth Intensive Care 26:420–423

    CAS  Article  Google Scholar 

  6. Maesaka JK, Gupta S, Fishbane S (1999) Cerebral salt-wasting syndrome: does it exist? Nephron 82:100–109

    CAS  Article  Google Scholar 

  7. Berkenbosch JW, Lentz CW, Jimenez DF, Tobias JD (2002) Cerebral salt wasting syndrome following brain injury in three pediatric patients: suggestions for rapid diagnosis and therapy. Pediatr Neurosurg 36:75–79

    Article  Google Scholar 

  8. Lee SJ, Huh EJ, Byeon JH (2004) Two cases of cerebral salt wasting syndrome developing after cerebral vault remodeling in craniosynostosis children. J Korean Med Sci 19:627–630

    Article  Google Scholar 

  9. Byeon JH, Yoo G (2005) Cerebral salt wasting syndrome after calvarial remodeling in craniosynostosis. J Korean Med Sci 20:866–869

    Article  Google Scholar 

  10. Sakarcan A, Mocchini J (1998) The role of fludrocortisone in a child with cerebral salt wasting. Pediatr Nephrol 12:769–771

    CAS  Article  Google Scholar 

  11. Huang SM, Chen CC, Chiu PC, Cheng MF, Chiu CL, Hsieh KS (2004) Tuberculous meningitis complicated with hydrocephalus and cerebral salt wasting syndrome in a three-year-old boy. Pediatr Infect Dis J 23:884–886

    Article  Google Scholar 

  12. Loo KL, Ramachandran R, Abdullah BJ, Chow SK, Goh EM, Yeap SS (2003) Cerebral infarction and cerebral salt wasting syndrome in a patient with tuberculous meningoencephalitis. Southeast Asian J Trop Med Public Health 34:636–640

    CAS  PubMed  Google Scholar 

  13. Dass R, Nagaraj R, Murlidharan J, Singhi S (2003) Hyponatremia and hypovolemic shock with tuberculous meningitis. Indian J Pediatr 70:995–997

    Article  Google Scholar 

  14. Brookes MJ, Gould TH (2003) Cerebral salt wasting syndrome in meningoencephalitis: a case report. J Neurol Neurosurg Psychiatry 74:277

    CAS  Article  Google Scholar 

  15. Namba T, Harada T, Sakai K, Takeji M, Takahara K, Uzu T, Yamauchi A (2006) Cerebral salt wasting syndrome in a patient with viral meningoencephalitis. Jpn J Nephrol 48:669–674 (in Japanese)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Takashi Sekine.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Inatomi, J., Yokoyama, Y., Sekine, T. et al. A case of cerebral salt-wasting syndrome associated with aseptic meningitis in an 8-year-old boy. Pediatr Nephrol 23, 659–662 (2008). https://doi.org/10.1007/s00467-007-0679-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-007-0679-8

Keywords

  • Cerebral salt wasting syndrome (CSWS)
  • Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
  • Hyponatremia
  • Aseptic meningitis