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Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis

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Abstract

Acquired abnormalities of coagulation and fibrinolysis in nephrotic syndrome have been implicated in the pathogenesis of deep-vein and arterial thrombosis. A mutation in the factor V and methylenetetrahydrofolate reductase (MTHFR) gene, the commonest inherited risk factor for venous thrombosis, may contribute to the risk of both arterial and deep-vein thrombosis in patients with nephrotic syndrome. Here, we report on an arterial thrombosis in a young girl with idiopathic membranous glomerulonephritis associated with heterozygous factor V Leiden and homozygous MTHFR C677T mutation. We postulate that screening for factors such as factor V Leiden and MTHFR C677T mutation may be beneficial to patients associated with thromboembolism and idiopathic nephrotic syndrome.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Gaziantep University Faculty of Medicine, Sahinbey , Gaziantep, 27310, Turkey

    Mithat Büyükçelik & Ayşe Balat

  2. Department of Pathology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

    Metin Karakök

  3. Department of Pediatric Cardiology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

    Osman Başpınar

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  1. Mithat Büyükçelik
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  2. Metin Karakök
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  3. Osman Başpınar
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  4. Ayşe Balat
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Correspondence to Mithat Büyükçelik.

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Büyükçelik, M., Karakök, M., Başpınar, O. et al. Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis. Pediatr Nephrol 23, 491–494 (2008). https://doi.org/10.1007/s00467-007-0657-1

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  • DOI: https://doi.org/10.1007/s00467-007-0657-1

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