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Effect of tangerine juice on cyclosporine levels in renal transplant children

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Abstract

The aim of our study was to investigate the effect of tangerine juice on the pharmacokinetics of cyclosporine A (CsA), in children who had received a renal transplant. This placebo-controlled study was done on ten kidney transplant recipients with stable cyclosporine trough levels who received either tangerine (Unshio Satsuma) juice or water. Patients were given their morning doses of CsA and then 250 ml water or the juice, and 12 h, investigations of the pharmacokinetics (PK) were performed. The main outcome measures were peak concentration and time to peak and area under the concentration–time curve. Administration of CsA with tangerine juice compared with water did not increase significantly the area under the whole-blood concentration versus time curve from 0–12 h (AUC0–12) of CsA, (tangerine juice 2,797 ± 1,361 (P = 0.5); water 3,053 ± 1,532). Co-administration of tangerine juice with CsA compared with water had no significant effects on the AUC0–12, peak concentration (Cmax) or time to Cmax (tmax) of the CsA in pediatric renal transplantation.

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Acknowledgment

We are grateful to the Research Council and Pediatric Research Center of Babol Medical University, which supported this study.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Pediatric Research Center, Amirkola Children’s Hospital, Faculty of Medicine, Babol University of Medical Sciences, Babol, 47317-41151, Iran

    Hadi Sorkhi, Farshid Oaliaee, Abazar Akbarzadeh Pasha & Mohammad Rad Goodarzi

  2. Department of Kidney Transplantation, Babol University of Medical Sciences, Babol, Iran

    Hadi Sorkhi, Farshid Oaliaee, Abazar Akbarzadeh Pasha & Mohammad Rad Goodarzi

  3. Department of Pharmacology, Babol University of Medical Sciences, Babol, Iran

    Ali Akbar Moghadamnia

  4. Department of Biochemistry, Babol University of Medical Sciences, Babol, Iran

    Mehdi PourAmir

  5. Department of Pathology, Babol University of Medical Sciences, Babol, Iran

    Ali Reza Firoozjahi

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  1. Hadi Sorkhi
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  2. Ali Akbar Moghadamnia
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  3. Farshid Oaliaee
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  4. Mehdi PourAmir
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  5. Ali Reza Firoozjahi
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  6. Abazar Akbarzadeh Pasha
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  7. Mohammad Rad Goodarzi
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Correspondence to Hadi Sorkhi.

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Sorkhi, H., Moghadamnia, A.A., Oaliaee, F. et al. Effect of tangerine juice on cyclosporine levels in renal transplant children. Pediatr Nephrol 23, 499–501 (2008). https://doi.org/10.1007/s00467-007-0655-3

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  • DOI: https://doi.org/10.1007/s00467-007-0655-3

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