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Risk factors for renal scarring in children and adolescents with lower urinary tract dysfunction

Pediatric Nephrology volume 22, pages 1891–1896 (2007)Cite this article

Abstract

Risk factors for renal scarring in children with lower urinary tract dysfunction (LUTD) were evaluated. The medical records of 120 patients were assessed concerning gender, presence of vesicoureteric reflux (VUR), bladder capacity, detrusor overactivity, residual urine, febrile urinary tract infection (UTI), bacteriuria, constipation, detrusor sphincter incoordination (DSI), high detrusor pressure at maximal cystometric capacity (PMCC), low compliance, and thickness and trabeculation of the bladder wall. Renal scarring was diagnosed by 99mtechnetium-dimercaptosuccinic acid renal scan (DMSA). Renal scarring was detected in 38 patients (31%). VUR, UTI, decreased bladder capacity, urinary residue, and trabeculated and thick bladder wall were associated with scarring at univariate analysis. Multivariate analysis showed VUR (P < 0.0001) as the independent risk factor for renal scarring. Thickness of the bladder wall was a marginal risk factor (P= 0.07). Although UTI was not a risk factor, it was associated with VUR (P= 0.03). In our analysis, VUR was the main risk factor; however, renal scarring was probably due to multifactorial causes, as VUR was associated with UTI.

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Affiliations

  1. Pediatric Nephrourology Unit, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Cristiane R. Leonardo, Maria Francisca T. Filgueiras, Mônica M. Vasconcelos, Roberta Vasconcelos, Viviane P. Marino, Cleidismar Pires, Eduardo A. Oliveira & Eleonora M. Lima

  2. Brazilian National Research Council (CNPq), Hospital das Clínicas, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

    Ana Cristina Pereira & Fernanda Reis

  3. Rua Américo Werneck, 195, Mangabeiras, Belo Horizonte, Minas Gerais, Brazil

    Cristiane R. Leonardo

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  1. Cristiane R. Leonardo
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  2. Maria Francisca T. Filgueiras
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  3. Mônica M. Vasconcelos
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  4. Roberta Vasconcelos
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  5. Viviane P. Marino
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  6. Cleidismar Pires
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  8. Fernanda Reis
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  9. Eduardo A. Oliveira
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  10. Eleonora M. Lima
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Correspondence to Cristiane R. Leonardo.

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Leonardo, C.R., Filgueiras, M.F.T., Vasconcelos, M.M. et al. Risk factors for renal scarring in children and adolescents with lower urinary tract dysfunction. Pediatr Nephrol 22, 1891–1896 (2007). https://doi.org/10.1007/s00467-007-0564-5

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  • DOI: https://doi.org/10.1007/s00467-007-0564-5

Keywords

  • Neurogenic bladder
  • Nonneurogenic bladder
  • Renal scarring
  • Children