Abstract
An infant with a suspected inborn metabolism error was treated with a metabolic cocktail of intravenous sodium phenylacetate (NaPh) and sodium benzoate (NaBz) for hyperammonemia. Sequential hemodialysis (HD) then hemofiltration (HF) was performed due to hyperammonemia. Dialytic and convective clearance (K; ml/min) of ammonia, NaPh, and NaBz was measured. The K of ammonia was 57 and 37 for HD and HF, respectively. The K of NaBz was 37 and 12 for HD and HF, respectively. The K of NaPh was 38 and 14 ml/min for HD and HF, respectively. Despite high clearance of both NaPh and NaBz by HD and HF, the hyperammonemia was corrected.
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Acknowledgment
The authors are indebted to the metabolics laboratory of Drs. Mendel Tuchman and Robert B. MacArthur, without whose assistance the plasma measurements of sodium phenylacetate and sodium benzoate could not have been determined.
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Bunchman, T.E., Barletta, GM., Winters, J.W. et al. Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration. Pediatr Nephrol 22, 1062–1065 (2007). https://doi.org/10.1007/s00467-007-0436-z
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DOI: https://doi.org/10.1007/s00467-007-0436-z