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Unusual histological findings in a child with idiopathic nephrotic syndrome

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Abstract

We report a 2-year-old child with corticosteroid-resistant nephrotic syndrome whose renal biopsy revealed light microscopically normal glomeruli but highly unusual finger-like projections and arches of the glomerular basement membrane. To our knowledge, the association between nephrotic syndrome and this patient’s rare ultrastuctural lesion has not been previously documented in the literature. It is not certain whether this basement membrane is pathogenic or a striking but coincidental developmental anomaly.

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Authors and Affiliations

  1. Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY, 14214, USA

    James Springate

  2. Department of Pathology, The Ohio State University, Columbus, OH, 43210, USA

    Tibor Nadasdy

  3. Division of Nephrology, Women and Children’s Hospital, 219 Bryant Street, Buffalo, NY, 14222, USA

    James Springate

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  1. James Springate
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  2. Tibor Nadasdy
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Correspondence to James Springate.

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Springate, J., Nadasdy, T. Unusual histological findings in a child with idiopathic nephrotic syndrome. Pediatr Nephrol 22, 451–453 (2007). https://doi.org/10.1007/s00467-006-0330-0

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  • DOI: https://doi.org/10.1007/s00467-006-0330-0

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