Skip to main content

HLA-DRB1* alleles in Egyptian children with post-streptococcal acute glomerulonephritis

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

To investigate the association between HLA-DRB1* alleles and post-streptococcal acute glomerulonephritis (PSAGN) in Egyptian children, 32 unrelated patients with PSAGN and 380 healthy individuals from the same locality were typed for DRB1* alleles using the polymerase chain-reverse hybridization technique. Patients with PSAGN had significantly increased frequency of both DRB1* 03011 (46.9 vs. 19.2% in controls, P  = 0.00025) and DRB1* 1105 (31.1 vs. 15.6% in controls, P = 0.0097) alleles. However, after correction of P values, only the difference for DRB1* 03011 allele remained significant (Pc = 0.025). Their relative risks were significantly high (3.71, confidence interval [CI] = 1.8–7.8, and 3.57, CI = 1.4–8.9 respectively). No significant differences in the frequency of the two alleles were observed among patients with different grades of hypertension or proteinuria. In conclusion, DRB1* 03011, and possibly 1105, alleles confer susceptibility to PSAGN. However, the severity of the disease is not determined by these two alleles.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Glassock RJ, Brenner CM (1973) In: Brenner BM (ed) The kidney. Saunders, Philadelphia, p 961

    Google Scholar 

  2. 2.

    Braun DG, Schalch W, Schmid I (1980) In: Read SE, Zabriskie JB (eds) Streptococcal diseases and the immune response. Academic, New York, p 317

    Google Scholar 

  3. 3.

    Read SE, Reid H, Poon King T, Fischetti VA, Zabriskie JB, Rapaport FT (1977) HLA and predisposition to the non-suppurative sequelae of group A streptococcal infections. Transplant Proc 9:543–546

    CAS  PubMed  Google Scholar 

  4. 4.

    Layrisse Z, Rodriguez-Itrube B, Garcia-Ramirez R, Rodriguez A, Tiwari J (1983) Family studies of the HLA system in acute post streptococcal glomerulonephritis. Hum Immunol 7:177–185

    CAS  Article  Google Scholar 

  5. 5.

    Sasazuki T, Hayase R, Iwamoto I, Tsuchida H (1979) HLA and acute streptococcal glomerulonephritis. N Engl J Med 301:1184–1185

    CAS  PubMed  Google Scholar 

  6. 6.

    Unanue ER, Allen PM (1987) The basis for the immunoregulatory role and other accessory cells. Science 235:551–557

    Article  Google Scholar 

  7. 7.

    Marsh SG (1997) Nomenclature for factors of HLA system, update January/February. WHO Nomenclature Committee for Factors of HLA System. Hum Immunol 53:224

    CAS  Article  Google Scholar 

  8. 8.

    Bodmer WF (1997) HLA: what’s the name? A commentary on HLA nomenclature development over the years. Tissue Antigens 49:293–296

    CAS  Article  Google Scholar 

  9. 9.

    National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114(2 Suppl 4th report):555–576

    Article  Google Scholar 

  10. 10.

    Buyse I, Decorte R, Baens M, Cuppens H, Semana G, Emonds MP, Marynen P, Cassiman JJ (1993) Rapid DNA typing of class II HLA antigens using the polymerase chain reaction and reverse dot blot hybridization. Tissue Antigens 41:1–14

    CAS  Article  Google Scholar 

  11. 11.

    Thonnard J, Deldime F, Heusterspreute M, Delepaut B, Hanon F, De Bruyere M, Philippe M (1995) HLA class II genotyping: two assay systems compared. Clin Chem 41:553–556

    CAS  PubMed  Google Scholar 

  12. 12.

    Vaughan RW (1991) PCR-SSO typing for HLA-DRB alleles. Eur J Immunogen 18:69–80

    CAS  Article  Google Scholar 

  13. 13.

    Emery AEH (1976) In: Emery AEH (ed) Methodology in medical genetics, 1st edn. Churchill Livingstone, Edinburgh, p 98

    Google Scholar 

  14. 14.

    Bengtsson B, Thomson G (1981) Measuring the strength of association between HLA antigens and diseases. Tissue Antigens 18:356–363

    CAS  Article  Google Scholar 

  15. 15.

    Well WC (1812) Observation on dropsy which succeeds scarlet fever. Trans Soc Improve Med Chir Know 13:167–168

    Google Scholar 

  16. 16.

    Sasazuki T, Nishimura Y, Muto M, Ohta N (1983) Linked genes controlling the immune response and disease susceptibility. Immunol Rev 70:51–75

    CAS  Article  Google Scholar 

  17. 17.

    Tomai M, Kotb M, Majumdar G, Beachey EH (1990) Superantigenicity of streptococcal M protein. J Exp Med 172:359–362

    CAS  Article  Google Scholar 

  18. 18.

    Abe J, Forrester J, Nakahara T, Lafferty JA, Kotzin BL, Leung DY (1991) Selective stimulation of human T cells with streptococcal erythrogenic toxins A and B. J Immunol 146:3747–3750

    CAS  PubMed  Google Scholar 

  19. 19.

    Kotzin BL, Leung DY, Kappler J, Marrack P (1993) Superantigens and their potential role in human disease. Adv Immunol 54:99–166

    CAS  Article  Google Scholar 

  20. 20.

    Yoshizawa N, Treser G, McClung JA, Sagel I, Takahashi K (1983) Circulating immune complexes in patients with uncomplicated group A streptococcal pharyngitis and patients with acute post-streptococcal glomerulonephritis. Am J Nephrol 3:23–29

    CAS  Article  Google Scholar 

  21. 21.

    Tomlinson IP, Bodmer WF (1995) The HLA system and the analysis of multifactorial disease. Trends Genet 11:493–498

    CAS  Article  Google Scholar 

  22. 22.

    Imanishi T, Akaza T, Kimura A, Tokunaga K, Gojobori T (1992) Allele frequencies and haplotype frequencies for HLA and complement loci in various ethnic groups. In: Tsji K, Aizawa M, Sasazuki T (eds) HLA 1991. Oxford University Press, Oxford, pp 1065–220

    Google Scholar 

  23. 23.

    Mori K, Sasazuki T, Kimura A, Ito YP (1996) HLA-DP antigens and post-streptococcal acute glomerulonephritis. Acta Pediatr 85:916–918

    CAS  Article  Google Scholar 

  24. 24.

    Kotb M, Norrby-Teglund A, McGeer A, El-Sherbini H, Dorak MT, Khurshid A, Green K, Peeples J, Wade J, Thomson G, Schwartz B, Low DE (2002) An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med 8:1398–1404

    CAS  Article  Google Scholar 

  25. 25.

    Rees AG (1997) Immunogenetics of renal disease. In: Neilson EG, Couser WG (eds) Immunologic renal disease. Lippincott-Raven, Philadelphia, pp 99–120

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ashraf Bakr.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bakr, A., Mahmoud, L.AN., Al-Chenawi, F. et al. HLA-DRB1* alleles in Egyptian children with post-streptococcal acute glomerulonephritis. Pediatr Nephrol 22, 376–379 (2007). https://doi.org/10.1007/s00467-006-0324-y

Download citation

Keywords

  • Case-control study
  • HLA-DRB1*
  • Post-streptococcal acute glomerulonephritis