Abstract
Patients who survive the acute phase of postdiarrheal hemolytic uremic syndrome (D+ HUS) may develop renal complications after years of apparent recovery. The optimal regimen for monitoring these children is unclear. We therefore determined if screening for microalbuminuria, in the absence of overt proteinuria at follow-up, increased the sensitivity for predicting long-term renal-related sequelae. We found that screening for microalbuminurea, within the first 6–18 months following an episode of HUS, increased the sensitivity for predicting later sequelae from 22 to 66.7%, compared to screening for overt proteinuria alone. These findings, if confirmed by a larger cohort with more years of follow-up, may facilitate early initiation of intervention strategies designed to reduce progressive renal damage.
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We gratefully acknowledge the advice and assistance of Andrew Pavia, M.D.
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Dr. Randall M. Lou was a recipient of an International Society of Nephrology Fellowship Training Award.
This Research was partially funded by the Lois Joy Galler Foundation for the Hemolytic Uremic Syndrome.
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Lou-Meda, R., Oakes, R.S., Gilstrap, J.N. et al. Prognostic significance of microalbuminuria in postdiarrheal hemolytic uremic syndrome. Pediatr Nephrol 22, 117–120 (2007). https://doi.org/10.1007/s00467-006-0283-3
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DOI: https://doi.org/10.1007/s00467-006-0283-3