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Carotid artery thickness in children and young adults with end stage renal disease

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Abstract

Atherosclerosis is a major cause of morbidity and mortality for ESRD patients and we have little knowledge about the presence and risk factors of atherosclerosis in children with CRF. The measurement of carotid artery intima-media thickness (cIMT) using high-resolution ultrasonography is suggested as an excellent marker of subclinical atherosclerosis. In this study, we aimed to investigate the presence of atherosclerosis and to determine the relationship between atherosclerosis and some risk factors in children and young adults with ESRD. Thirty-four patients with ESRD and 20 controls were included in this study. The measurement of cIMT was performed by using a linear B-mode 7.5-MHz ultrasound transducer. We determined anemia, abnormal calcium/phosphate metabolism, hyperhomocysteinemia, hypertriglyceridemia and increased lipoprotein (a) levels in the ESRD group. The cIMT in the ESRD group was higher than in the control group (P<0.05). SBP, DBP, MAP, LVMI and LVH prevalence were statistically higher in the ESRD group (P<0.05). There were significant positive correlations between cIMT and LVMI, MBP, whereas a significant negative correlation was determined between cIMT and PTH in the ESRD group (P<0.05). When a multiple linear regression analysis was performed with cIMT as a dependent variable and LVMI, MBP, PTH, as independent variables, a significant positive correlation was determined between cIMT and LVMI (P<0.05). In conclusion, we think that arteriopathy occurs in children with ESRD. Left ventricular hypertrophy and hypertension may associate with vascular changes in children and young adults with ESRD. Further investigations are necessary to explain association of LVMI index with cIMT.

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Acknowledgements

This study was presented as poster presentation at 13th International Congress of the Pediatric Nephrology Association, Adelaide, Australia between August 29 and September 2, 2004.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Medical Faculty, Erciyes University, 38039, Kayseri, Turkey

    Hakan M. Poyrazoğlu, Ruhan Düşünsel & Zübeyde Gündüz

  2. Department of Radiology, Medical Faculty, Erciyes University, Kayseri, Turkey

    Ali Yıkılmaz & Abdulhakim Coşkun

  3. Department of Pediatric Cardiology, Medical Faculty, Erciyes University, Kayseri, Turkey

    Nazmi Narin & Ali Baykan

  4. Department of Biochemistry, Medical Faculty, Başkent University, Adana, Turkey

    Ruksan Anarat

  5. Department of Biostatistics, Medical Faculty, Erciyes University, Kayseri, Turkey

    Ahmet Öztürk

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  1. Hakan M. Poyrazoğlu
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  2. Ruhan Düşünsel
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Correspondence to Hakan M. Poyrazoğlu.

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Poyrazoğlu, H.M., Düşünsel, R., Yıkılmaz, A. et al. Carotid artery thickness in children and young adults with end stage renal disease. Pediatr Nephrol 22, 109–116 (2007). https://doi.org/10.1007/s00467-006-0268-2

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  • DOI: https://doi.org/10.1007/s00467-006-0268-2

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