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GFR is better estimated by considering both serum cystatin C and creatinine levels

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Serum cystatin C (cysC) is a potential marker of the glomerular filtration rate (GFR) that has generated conflicting reports in children. A prospective study was conducted to assess the benefit of considering cysC together with serum creatinine (SCr) and demographic and morphologic characteristics to better estimate the 51Cr-ethylenediaminetetraacetate (EDTA) clearance (CL), i.e., the GFR. Plasma 51Cr-EDTA data from 100 children or young adults (range: 1.4–22.8 years old) were analyzed according to the population pharmacokinetic approach by using the nonlinear mixed effects model (NONMEM) program. The actual CL was compared to the CL predicted according to different covariate equations. The best covariate equation (±95% confidence interval) was: GFR (ml/min)=63.2(±3.4) . [(SCr (μM)/96)−0.35 (±0.20)] . [(cysC (mg/l)/1.2)−0.56 (±0.19)] . [(body weight (kg)/45)0.30 (±0.17)] . [age (years)/14)0.40 (±0.16)]. This equation was associated with a less biased and more precise estimation than the Schwartz equation. CysC improves the estimation of the GFR in children if considered with other covariates within the mathematical formula.

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The authors thank Dade Behring (Marburg, Germany) for providing the analyzer and kits for the measurement of cystatin C. None of the authors has any conflict of interest to declare with respect to the contents of this article.

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Correspondence to Etienne Chatelut.

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Bouvet, Y., Bouissou, F., Coulais, Y. et al. GFR is better estimated by considering both serum cystatin C and creatinine levels. Pediatr Nephrol 21, 1299–1306 (2006).

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