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Health-related quality of life in pediatric patients with ESRD

Pediatric Nephrology volume 21, pages 846–850 (2006)Cite this article

Abstract

As part of creating a pediatric ESRD-specific Health-Related Quality of Life (HRQOL) assessment instrument, we established pilot data with the PedsQL 4.0 Generic Core Scales in 96 pediatric patients with ESRD receiving hemodialysis (HD), peritoneal dialysis (PD) or with a renal transplant (TX). Patient age ranges were: 2–4 (8; PD n=3, TX n=5), 5–7 (12; HD n=9, TX n=3), 8–12 (25; HD n=5, PD n=6, TX n=14), 13–18 (51; HD n=18, PD n=10, TX n=23). PedsQL ESRD data were compared to healthy children (n=131 child report; n=145 parent report) and across HD/PD/TX. For all domains, ESRD patient HRQOL scores were significantly lower than healthy controls. Transplant patients reported better physical and psychosocial health than dialysis patients. No difference was noted between HD and PD patients for any PedsQL domain. Our data demonstrate that the PedsQL 4.0 Generic Core Scales is a useful measurement instrument to screen for HRQOL impairment in pediatric patients with ESRD. We suggest that the ESRD-specific HRQOL instrument in development is needed to help define condition-specific HRQOL differences between modalities.

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Acknowledgements

The manuscript is dedicated to the memory of Rhonda Farrah, RN, whose commitment to the project was essential to its successful completion.

This work was supported by the Franklin McDonald/Fresenius Medical Care Clinical Research Award of the National Kidney Foundation.

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Authors and Affiliations

  1. Texas Children’s Hospital, 6621 Fannin Street, MC 3-2482, Houston, TX, 77030, USA

    Stuart L. Goldstein & Nicole Graham

  2. University of Washington, Washington, USA

    Tasha Burwinkle

  3. Children’s Mercy Hospital and Clinics, 2401 Gillham Road, Kansas, USA

    Bradley Warady & Rhonda Farrah

  4. Department of Pediatrics, College of Medicine, Texas, USA

    James W. Varni

  5. Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A&M University, Texas, USA

    James W. Varni

Authors
  1. Stuart L. Goldstein
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  2. Nicole Graham
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  3. Tasha Burwinkle
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  4. Bradley Warady
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  5. Rhonda Farrah
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  6. James W. Varni
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Correspondence to Stuart L. Goldstein.

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Goldstein, S.L., Graham, N., Burwinkle, T. et al. Health-related quality of life in pediatric patients with ESRD. Pediatr Nephrol 21, 846–850 (2006). https://doi.org/10.1007/s00467-006-0081-y

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  • DOI: https://doi.org/10.1007/s00467-006-0081-y

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