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Spurious hyperphosphatemia in a patient with alteplase-locked central venous catheter

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Abstract

Alteplase has been shown to be effective in preventing central venous access clotting in patients on hemodialysis. Because of a high phosphorus content in its excipient, it can inadvertently contaminate blood samples, leading the physician in care of the patient to erroneously increase dialysis time or change diet in order to control the pseudo-hyperphosphatemia.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Nephrology, University Hospital, Rue du Bugnon, 1011, Lausanne, Vaud, Switzerland

    Francois Cachat & Claudine Durussel

  2. Central Chemical Laboratory, University Hospital, Lausanne, Switzerland

    Daniel Bardy

  3. Department of Pharmacy, University Hospital, Lausanne, Switzerland

    Ermindo Di Paolo

Authors
  1. Francois Cachat
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  2. Daniel Bardy
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  3. Claudine Durussel
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  4. Ermindo Di Paolo
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Correspondence to Francois Cachat.

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Cachat, F., Bardy, D., Durussel, C. et al. Spurious hyperphosphatemia in a patient with alteplase-locked central venous catheter. Pediatr Nephrol 21, 301–302 (2006). https://doi.org/10.1007/s00467-005-2088-1

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  • DOI: https://doi.org/10.1007/s00467-005-2088-1

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