Abstract
Hypokalemia represents a rare cause of rhabdomyolysis. Some reports have described a few adult patients affected by Bartter’s syndrome and Gitelman’s syndrome with rhabdomyolysis due to severe hypokalemia. We report the first pediatric patient with Bartter’s syndrome in whom rhabdomyolysis developed when her plasma potassium level was less than 2 mEq/l. Prompt intravenous fluid and potassium prevented tubular damage and acute renal failure. We recommend determining serum creatine phosphokinase in all patients affected by Bartter’s syndrome and profound hypokalemia.
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References
Rodriguez-Soriano J (1999) Tubular disorders of electrolyte regulation. In: Barrat TM, Avner ED, Harmon WE (eds) Pediatric nephrology, 4th edn, Lippincott Williams and Wilkins, Baltimore, pp 545–563
Heberth SC (2003) Bartter syndrome. Curr Opin Nephrol Hypertens 12:527–532
Schlingmann KP, Konrad M, Jeck N, Waldegger P, Reinalter SC, Holder M, Seyberth HW, Waldegger S (2004) Salt wasting and deafness resulting from mutations in two chloride channels. N Engl J Med 350:1314–1319
Bierbach H, Bohl J, Goldner HJ, Majdandzic J (1983) Hypokalemic rhabdomyolysis associated with Bartter’s syndrome. Klin Wochenschr 61:183–186
van der Loos LJ (1986) Profound hypokalemia with rhabdomyolysis in Bartter’s syndrome. JAMA 256:2518
Nishihara G, Higashi H, Matsuo S, Yasunaga C, Sakemi T, Nakamoto M (1998) Acute renal failure due to hypokalemic rhabdomyolysis in Gitelman’s syndrome. Clin Nephrol 50:330–332
Delaporte C, Stulzaft J, Loirat C, Broyer M (1978) Muscle electrolytes and fluid compartments in six children with Bartter’s syndrome. Clin Sci Mol Med 54:223–231
Maresca MC, Calconi G, Amici GP, Teodori T, Da Porto A (1988) Hypopotassemia and rhabdomyolysis. Description of 3 cases of different etiologies. Minerva Med 79:55–60
Brumback RA, Feeback DL, Leech RW (1992) Rhabdomyolysis in childhood. A primer on normal muscle function and selected metabolic myopathies characterized by disordered energy production. Pediatr Clin North Am 39:821–858
Watanabe T (2001) Rhabdomyolysis and acute renal failure in children. Pediatr Nephrol 16:1072–1075
Menahem SA, Perry GJ, Dowling J, Thomson NM (1999) Hypokalaemia-induced acute renal failure. Nephrol Dial Transplant 14:2216–2218
Konrad M, Vollmer M, Lemmink HH, van den Heuvel LPWJ, Jeck N, Vargas-Poussou R, Lakings A, Rainer R, Deschenes G, Antignac C, Guay-Woodford L, Knoers NVAM, Seyberth HW, Feldmann D, Hildebrandt F (2000) Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter syndrome. J Am Soc Nephrol 11:1449–1459
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Pela, I., Materassi, M., Seracini, D. et al. Hypokalemic rhabdomyolysis in a child with Bartter’s syndrome. Pediatr Nephrol 20, 1189–1191 (2005). https://doi.org/10.1007/s00467-005-1916-7
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DOI: https://doi.org/10.1007/s00467-005-1916-7