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Genetic polymorphisms and risk for acute renal failure in preterm neonates

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Abstract

Acute renal failure (ARF) affects about 10% of severely ill neonates. Recent studies have shown that genetic polymorphisms of proteins that play a role in neonatal physiology may contribute to individual susceptibility to both ARF and its risk factors. Our review summarizes the data collected to date. Studies have shown that the risk of preterm neonates for ARF is directly associated with a combination of high tumor necrosis factor-α producer and low interleukin-6 producer genotypes, as well as with low heat shock protein 72 producer genotype. Premature birth is itself the most important risk factor for a number of complications, including ARF, and recent studies have also shown an association between several maternal and fetal cytokine genetic polymorphisms and increased inflammatory response in preterm neonates. These polymorphisms could also be associated with increased risk for disorders such as sepsis and necrotizing enterocolitis, which lead to renal hypoperfusion and ARF. Genetic polymorphisms of the renin-angiotensin-aldosterone system have not been shown to directly influence risk for ARF. They may, however, be associated with patent ductus arteriosus, poor postnatal adaptation, and heart failure, which are all prevalent risk factors for ARF.

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Acknowledgements

This study was financially supported by OTKA grant T046086 and T 034605.

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Authors and Affiliations

  1. Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary

    Barna Vásárhelyi & Tivadar Tulassay

  2. First Department of Pediatrics, Semmelweis University, Budapest, Hungary

    Péter Tóth-Heyn, András Treszl & Tivadar Tulassay

  3. First Department of Pediatrics, Bókay u. 53, 1083, Budapest, Hungary

    Tivadar Tulassay

Authors
  1. Barna Vásárhelyi
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  2. Péter Tóth-Heyn
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  3. András Treszl
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  4. Tivadar Tulassay
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Correspondence to Tivadar Tulassay.

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Vásárhelyi, B., Tóth-Heyn, P., Treszl, A. et al. Genetic polymorphisms and risk for acute renal failure in preterm neonates. Pediatr Nephrol 20, 132–135 (2005). https://doi.org/10.1007/s00467-004-1711-x

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  • DOI: https://doi.org/10.1007/s00467-004-1711-x

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