Abstract
Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-β1 (TGF-β) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-β was detected in the urine of 52% of 48 children aged 1–24 months with a first episode of UTI (94% due to Escherichia coli) and no obstructive nephropathy compared with 0 of 20 healthy young children (P<0.001). TGF-β was detected in the urine only during the early stage (<1 day) after initiation of treatment. It was detected more frequently (P=0.06) and in significantly higher concentrations (P=0.046) in children with a normal 99m Tc-dimercaptosuccinic acid scan compared with those with abnormal scans performed 3–14 days after the diagnosis of UTI, suggesting a regulatory role in fibrogenesis and outcome of pyelonephritis in childhood.
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Acknowledgements
The technical expertise and dedication of Avgi Maloukou, MT, is gratefully acknowledged. We also thank Dr. Ekaterini Papachristou, Head, and Fani Dogramatzi from the Chemistry Laboratory, Hippokration Hospital for the measurement of urine creatinine concentrations. Some of these data have been presented at the 42nd Interscience Conference Antimicrobial Agents Chemotherapy, San Diego Calif., September 2002, p 252 (abstract number J-1463).
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Farmaki, E., Papachristou, F., Winn, R.M. et al. Transforming growth factor-β1 in the urine of young children with urinary tract infection. Pediatr Nephrol 20, 180–183 (2005). https://doi.org/10.1007/s00467-004-1705-8
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DOI: https://doi.org/10.1007/s00467-004-1705-8