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Aminophylline as an adjunct diuretic for neonates—a case series

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Abstract

Aminophylline is an adenosine receptor antagonist. Adult and paediatric studies have demonstrated a diuretic effect of aminophylline due to increased renal blood flow and the inhibition of solute reabsorption in various segments of the nephron. We report a case series of five infants with volume overload despite frusemide treatment. Aminophylline was successfully used as an adjunct diuretic with increased urine output and effective weight loss occurring in all five neonates following its introduction.

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References

  1. Noguchi T, Hayano Y, Iwasaka H, Setoguchi K, Odi S, Taniguchi K, Honda N, Mori R, Hadama T (1990) Diuretic effects of aminophylline in patients after cardiac surgery. Masui 39:1002–1006

    CAS  PubMed  Google Scholar 

  2. Good J, Frost G, Oakley CM, Cleland JG (1992) The renal effects of dopamine and dobutamine in stable chronic heart failure. Postgrad Med J 68 [Suppl 2]:S7–S11

  3. Seri I, Rudas G, Bors Z, Kanyicska B, Tulassay T (1993) Effects of low-dose dopamine infusion on cardiovascular and renal functions, cerebral blood flow, and plasma catecholamine levels in sick preterm neonates. Pediatr Res 34:742–749

    CAS  PubMed  Google Scholar 

  4. Gottlieb SS, Brater DC, Thomas I, Havranek E, Bourge R, Goldman S, Dyer F, Gomez M, Bennett D, Ticho B, Beckman E, Abraham WT (2002) BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 105:1348–1353

    Article  CAS  PubMed  Google Scholar 

  5. Gottlieb SS, Skettino SL, Wolff A, Beckman E, Fisher ML, Freudenberger R, Gladwell T, Marshall J, Cines M, Bennett D, Liittschwager EB (2000) Effects of BG9719 (CVT-124), an A1-adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in patients with congestive heart failure. J Am Coll Cardiol 35:56–59

    Article  CAS  PubMed  Google Scholar 

  6. Shirley DG, Walter SJ, Noormohamed FH (2002) Natriuretic effect of caffeine: assessment of segmental sodium reabsorption in humans. Clin Sci (Colch) 103:461–466

    Google Scholar 

  7. Pretzlaff RK, Vardis RJ, Pollack MM (1999) Aminophylline in the treatment of fluid overload. Crit Care Med 27:2782–2785

    Article  CAS  PubMed  Google Scholar 

  8. Mazkereth R, Laufer J, Jordan S, Pomerance JJ, Boichis H, Reichman B (1997) Effects of theophylline on renal function in premature infants. Am J Perinatol 14:45–49

    CAS  PubMed  Google Scholar 

  9. Ahn HW, Shin WG, Park KJ, Suh OK, Choi JH (1999) Pharmacokinetics of theophylline and caffeine after intravenous administration of aminophylline to premature neonates in Korea. Res Commun Mol Pathol Pharmacol 105:105–113

    CAS  PubMed  Google Scholar 

  10. Lowry JA, Jarrett RW, Wasserman G, Pettett G, Kauffmann RE (2001) Theophylline toxicokinetics in premature newborns. Arch Pediatr Adolesc Med 155:934–939

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neonatology, St George’s Hospital, Tooting, London, UK

    Geraldine Yin Taeng Ng & Katharine Florence Mary Farrer

  2. Department of Physiological Medicine, St George’s Hospital, Tooting, London, UK

    Emma Harriet Baker

  3. Neonatal Intensive Care Unit, 1st Floor, Lanesborough Wing, St George’s Hospital, Blackshaw Road, London, SW17 0RE, UK

    Geraldine Yin Taeng Ng

Authors
  1. Geraldine Yin Taeng Ng
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  2. Emma Harriet Baker
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  3. Katharine Florence Mary Farrer
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Correspondence to Geraldine Yin Taeng Ng.

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Ng, G.Y.T., Baker, E.H. & Farrer, K.F.M. Aminophylline as an adjunct diuretic for neonates—a case series. Pediatr Nephrol 20, 220–222 (2005). https://doi.org/10.1007/s00467-004-1692-9

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  • DOI: https://doi.org/10.1007/s00467-004-1692-9

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