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Molecular physiology, pathology, and regulation of the growth hormone/insulin-like growth factor-I system

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Abstract

Since the somatomedin hypothesis of growth hormone (GH) action was first formulated nearly 50 years ago, the key roles of both GH and insulin-like growth factor (IGF)-I in human growth have been confirmed and extended to include local effects on tissue maintenance and repair. More recent insights have revealed a dark side to the GH/IGF-I signaling system. Both proteins have been implicated as potential contributing factors in selected human cancers, and normal activity through this signaling pathway has been linked to diminished lifespan in experimental animals. This review highlights both the positive and negative aspects of the GH/IGF-I-growth pathway. The overall goal is to reinforce the need for more complete understanding of the mechanisms of signaling and action of GH and IGF-I, in order to separate, if possible, the potentially beneficial outcomes on growth and on tissue maintenance and repair from deleterious effects on cancer risk and lifespan.

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Acknowledgements

Research cited from our laboratory was supported by grants from the U. S. National Institutes of Health. J.W. was supported by a research fellowship from the European Society for Pediatric Endocrinology sponsored by Novo Nordisk and the Eli Lilly International Foundation. D.J.C. was supported by a research fellowship from the Lawson Wilkins Pediatric Endocrinology Society sponsored by Eli Lilly.

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Authors and Affiliations

  1. Molecular Medicine Division, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA

    Joachim Woelfle, Dennis J. Chia, Mylynda B. Massart-Schlesinger, Paula Moyano & Peter Rotwein

  2. Division of Endocrinology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA

    Dennis J. Chia

  3. Molecular Medicine Division, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Road, Mail code HRC3, Portland, OR 97239–3098, USA

    Peter Rotwein

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  1. Joachim Woelfle
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  2. Dennis J. Chia
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  3. Mylynda B. Massart-Schlesinger
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  4. Paula Moyano
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  5. Peter Rotwein
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Corresponding author

Correspondence to Peter Rotwein.

Additional information

This work was presented in part at the IPNA Seventh Symposium on Growth and Development in Children with Chronic Kidney Disease: The Molecular Basis of Skeletal Growth, 1–3 April 2004, Heidelberg, Germany

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Woelfle, J., Chia, D.J., Massart-Schlesinger, M.B. et al. Molecular physiology, pathology, and regulation of the growth hormone/insulin-like growth factor-I system. Pediatr Nephrol 20, 295–302 (2005). https://doi.org/10.1007/s00467-004-1602-1

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  • DOI: https://doi.org/10.1007/s00467-004-1602-1

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