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Cystatin C is a suitable marker of glomerular function in children with cancer

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Abstract

Antineoplastic chemotherapy is associated with nephrotoxic side effects. Data on nephrotoxicity in childhood cancer are scanty, in part because of the difficulties in obtaining reliable markers of glomerular function. We used serum cystatin C (cysC) to assess glomerular function. CysC was compared with serum creatinine concentration (SCr), the endogenous creatinine clearence ( C Cr), and the calculated Counahan formula ( C Counahan) in children with leukemia and solid tumors. CysC was measured by particle-enhanced immunoturbidimetric assay. Serum and urinary creatinine concentrations were determined by the Jaffé method. Samples were obtained from 258 children, including 92 receiving anticancer chemotherapy, 108 long-term survivors, 40 children without any renal disease, and 18 patients with chronic renal insufficiency. CysC of patients on current chemotherapy was assessed both before and after treatment. Significant correlations were found between cysC and SCr and between 1/cysC and C Counahan. CysC increased significantly after cisplatin, methotrexate, cyclophosphamide, ifosfamide, and multimodality treatment. Our results suggest that cysC measurement can be used to characterize glomerular function in children with cancer.

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Acknowledgement

Statistical analysis was performed by Zsolt Karányi. This work was supported by a grant from the Health Science Council of the Ministry of Health, Republic of Hungary (ETT) no. 225 and by the “For the Leukemic Children” and “Hope for the Leukemic Children” Foundations.

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Authors and Affiliations

  1. Department of Pediatrics, Medical and Health Science Center, University of Debrecen, Hungary

    Edit Bárdi, Ildikó Bobok, Éva Oláh & Csongor Kiss

  2. Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Hungary

    Anna V. Oláh & János Kappelmayer

  3. Pediatric Department, Medical and Health Science Center, University of Debrecen, 98 Nagyerdei Circle, P.O. Box 32, 4012, Debrecen, Hungary

    Edit Bárdi

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  1. Edit Bárdi
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  2. Ildikó Bobok
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  3. Anna V. Oláh
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  4. Éva Oláh
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  5. János Kappelmayer
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  6. Csongor Kiss
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Correspondence to Edit Bárdi.

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Bárdi, E., Bobok, I., Oláh, A.V. et al. Cystatin C is a suitable marker of glomerular function in children with cancer. Pediatr Nephrol 19, 1145–1147 (2004). https://doi.org/10.1007/s00467-004-1548-3

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  • DOI: https://doi.org/10.1007/s00467-004-1548-3

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